Chitosan/polypropylene glycol hydrogel composite film designed with TiO2 nanoparticles: A promising scaffold of biomedical applications

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dc.authoridUlu, Ahmet/0000-0002-4447-6233
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authorwosidUlu, Ahmet/L-5180-2016
dc.authorwosidKöytepe, Süleyman/AAA-4168-2021
dc.authorwosidBirhanli, Emre/AAA-4009-2021
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorUlu, Ahmet
dc.contributor.authorBirhanli, Emre
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:48:44Z
dc.date.available2024-08-04T20:48:44Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe present study explores the preparation and characterization of chitosan/poly (propylene glycol)/titanium dioxide (CH/PPG/TiO2) composite hydrogels in view of their developing applications such as antimicrobial packaging, wound dressing and antibacterial materials. The prepared CH/PPG/TiO2 films were comprehensively characterized by several methods. The size distribution showed the average size of the TiO2 nanoparticles (NPs) was about 40 nm. Additionally, other properties including swelling ratio, water retention, water contact angle, porosity, water uptake, in vitro enzymatic degradation, water vapor transmission rate, in vitro biomineralization studies, and mechanical tests were evaluated in detailed. Besides these characterizations, the antimicrobial activity of CH/PPG/TiO2 composite film against Staphylococcus aureus, Escherichia coli, and Candida lipolytica was evaluated by using disc diffusion method. Based on the obtained results, the CH/PPG/TiO2 composite hydrogels showed enhanced water vapor permeability, porosity, water retention, and swelling ratio. An improvement was observed in the examined mechanical and thermal properties with the addition of TiO2 NPs. The tensile strength and elongation at break values of CH/PPG/TiO2 were 3.0 MPa and 31%, respectively. Most importantly, the CH/PPG/TiO2 composite hydrogels showed strong antimicrobial properties. Finally, the developed composite scaffold prepared in this study may possess potentially useful in biomedical applications. (C) 2020 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijbiomac.2020.07.015
dc.identifier.endpage540en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid32640322en_US
dc.identifier.scopus2-s2.0-85087690407en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage529en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2020.07.015
dc.identifier.urihttps://hdl.handle.net/11616/99405
dc.identifier.volume163en_US
dc.identifier.wosWOS:000579839600054en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChitosanen_US
dc.subjectPolypropylene glycolen_US
dc.subjectTiO2 nanoparticlesen_US
dc.subjectComposite hydrogel membraneen_US
dc.subjectAntimicrobial activityen_US
dc.titleChitosan/polypropylene glycol hydrogel composite film designed with TiO2 nanoparticles: A promising scaffold of biomedical applicationsen_US
dc.typeArticleen_US

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