Evaluation of the antioxidant effects of melatonin on the larynx mucosa of rats exposed to environmental tobacco smoke

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridUzun, Hafize/0000-0002-1347-8498
dc.authorwosiddastan, sevgi durna/AAO-8476-2021
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidUzun, Hafize/D-4811-2019
dc.contributor.authorDonmez, Z.
dc.contributor.authorYigit, O.
dc.contributor.authorBilici, S.
dc.contributor.authorDursun, N.
dc.contributor.authorGul, M.
dc.contributor.authorDastan, S. D.
dc.contributor.authorUzun, H.
dc.date.accessioned2024-08-04T20:41:32Z
dc.date.available2024-08-04T20:41:32Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: This study's aim was to investigate the effect of melatonin in terms of mitigating the effects of smoking on the laryngeal mucosa of rats exposed to environmental tobacco smoke. Design: Rats were divided into four groups: Melatonin + Smoking group exposed to smoke with melatonin; Smoking group exposed to smoke without melatonin; Saline group not exposed to smoke without melatonin; Melatonin group not exposed to smoke with melatonin. CuZn-superoxide dismutase (CuZn-SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities were evaluated in plasma and tissues. Tissues were also examined the changes of squamous hyperplasia, keratosis, parakeratosis and epithelial hyperplasia by light microscope and the ultrastructural changes by electron microscope. Results: Tissue SOD, CAT and GSH-Px activities were significantly higher in Saline and Melatonin groups than Melatonin + Smoking and Smoking groups. Plasma CuZn-SOD and CAT activities were significantly higher in Saline and Melatonin groups than Smoking group. Plasma GSH-Px showed no significant difference. The rate of epithelial hyperplasia was significantly higher in Smoking group than the other groups. The rate of parakeratosis was significantly higher in Smoking group than the other groups. The epithelial cells in Melatonin + Smoking group displayed, normal cell structure similar to those in Saline group under electron microscope. Conclusions: The study shows that smoking induces substantial pathological changes in the laryngeal mucosa and melatonin may have some beneficial effects in partially reversing smoking-induced laryngeal injury by inducing the expression of antioxidants; biochemical and histological outcomes also support these findings due to preventing tissue damage in laryngeal mucosa exposed to smoke.en_US
dc.identifier.doi10.1111/coa.12501
dc.identifier.endpage221en_US
dc.identifier.issn1749-4478
dc.identifier.issn1749-4486
dc.identifier.issue3en_US
dc.identifier.pmid26147283en_US
dc.identifier.scopus2-s2.0-84959046439en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage211en_US
dc.identifier.urihttps://doi.org/10.1111/coa.12501
dc.identifier.urihttps://hdl.handle.net/11616/97189
dc.identifier.volume41en_US
dc.identifier.wosWOS:000375075200002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical Otolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative Stressen_US
dc.subjectNicotineen_US
dc.subjectDamageen_US
dc.subjectLiveren_US
dc.subjectKeratosisen_US
dc.subjectInjuryen_US
dc.titleEvaluation of the antioxidant effects of melatonin on the larynx mucosa of rats exposed to environmental tobacco smokeen_US
dc.typeArticleen_US

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