Investigation of the protective effect of Lavandula stoechas against the damage caused by Bisphenol A in the liver tissue of rats

Basit Öğe Kaydı
dc.contributor.authorAydın, Merve
dc.contributor.authorKöse, Evren
dc.contributor.authorTaşlıdere Karaca, Elif
dc.contributor.authorTanbek, Kevser
dc.contributor.authorSandal, Süleyman
dc.date.accessioned2026-04-04T13:18:55Z
dc.date.available2026-04-04T13:18:55Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractThe present study aims to explore the hepatoprotective potential of Lavandula stoechas (LS) against Bisphenol A (BPA)-induced liver toxicity. In this experiment, 32 male rats were utilized and categorized into control, LS, BPA, and BPA + LS groups for the study. Each group received 50 mg/kg of the respective substance. Throughout the 28-day experiment, the control group did not receive any applications. The LS oil was administered intraperitoneally, while BPA was given through oral gavage. At the end of the experiment, rats were anesthetized, and blood was taken from the heart. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TB) values were measured from serum samples. Malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) measurements were performed in liver tissue. The histological structure was observed using hematoxylin and eosin staining methods. The BPA group showed higher AST levels compared to the control group, but the BPA + LS group exhibited a significant decrease in AST levels compared to the BPA group. Additionally, TB levels were lower in the BPA + LS group compared to the BPA group. MDA levels increased in BPA-treated groups compared to others. The LS-treated groups showed higher SOD levels compared to the control group. Furthermore, an evident increase was noted in the BPA + LS group in comparison to the BPA group. The BPA group exhibited a significant rise in OSI value compared to the control. It was concluded that LS has a protective impact against BPA-induced liver toxicity. The LS-treated groups showed higher SOD levels compared to the control group. Furthermore, a significant increase was noted in the BPA + LS group in comparison to the BPA group. The BPA group exhibited a significant rise in OSI value compared to the control. It was concluded that LS has a protective impact against BPA-induced liver toxicity. © 2024
dc.description.sponsorshipİnönü University Scientific Research Foundation, (2021-2775)
dc.identifier.doi10.1016/j.heliyon.2024.e39386
dc.identifier.issn2405-8440
dc.identifier.issue20
dc.identifier.scopus2-s2.0-85206178899
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.heliyon.2024.e39386
dc.identifier.urihttps://hdl.handle.net/11616/108010
dc.identifier.volume10
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofHeliyon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250329
dc.subjectBisphenol A
dc.subjectLavandula stoechas
dc.subjectLiver
dc.subjectOxidative stress
dc.titleInvestigation of the protective effect of Lavandula stoechas against the damage caused by Bisphenol A in the liver tissue of rats
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu