Oral colonization of Acinetobacter baumannii in intensive care units: Risk factors, incidence, molecular epidemiology, association with the occur of pneumonia and sepsis, and infection control measures

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dc.authoridErsoy, Yasemin/0000-0001-5730-6682
dc.authoridtoplu, sibel altunışık/0000-0002-2915-4666
dc.authoridTanriverdi, Elif Seren/0000-0002-0449-0356
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridDuman, Yucel/0000-0002-9090-2096
dc.authoridOtlu, Baris/0000-0002-6220-0521
dc.authorwosidErsoy, Yasemin/AAE-4811-2020
dc.authorwosidtoplu, sibel altunışık/ABH-5816-2020
dc.authorwosidTanriverdi, Elif Seren/ABE-4472-2021
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidDuman, Yucel/AAU-6221-2020
dc.contributor.authorDuman, Yucel
dc.contributor.authorErsoy, Yasemin
dc.contributor.authorTanriverdi, Elif Seren
dc.contributor.authorOtlu, Bans
dc.contributor.authorToplu, Sibel Altunisik
dc.contributor.authorGoziikara, GOzde
dc.contributor.authorTekerekoglu, Mehmet Sait
dc.date.accessioned2024-08-04T20:51:44Z
dc.date.available2024-08-04T20:51:44Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective(s): Oral colonization of Acinetobacter baumannii can lead to infections such as pneumonia and sepsis. We aimed to evaluate oral colonization of hospitalized patients in ICUs and to examine risk factors for oral colonization, molecular epidemiology, and incidence of pneumonia and sepsis. Materials and Methods: The study began in February 2021. Oral cultures were taken. The microorganisms were identified by a Maldi-tof MS mass spectrometry device. Colistin resistance genes were investigated by polymerase chain reaction. Clonal relationships were determined by pulsed-field gel electrophoresis. Results: A. baumannii was found in 21 of 96 patients' oral cultures. Pneumonia and sepsis due to A. baumannii were detected in 14 and 5 patients, respectively. The mean growth time of A. baumannii from oral cultures was 11.8 days, and the meantime for the occurrence of pneumonia after oral growth was 5.2 days. We determined a plasmid mediated mcr-2 colistin resistance gene in a colistin susceptible A. baumannii strain. It is the first report of the plasmid mediated mcr-2 colistin resistance gene in our country. In total, fourteen different A. baumannii genotypes were determined in PFGE. It was determined that the effects of antibiotic use, oral motor dysfunction, mechanical ventilation, intubation, orogastric tube use, and total parenteral nutrition intake on oral colonization were statistically significant. Conclusion: Oral colonization of A. baumannii is a significant concern in ICUs. We believe that it is important to take oral cultures and follow the risk factors and take infection control measures to prevent oral colonization of resistant isolates in ICUs.en_US
dc.identifier.doi10.22038/IJBMS.2022.59713.13243
dc.identifier.endpage244en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue2en_US
dc.identifier.pmid35655587en_US
dc.identifier.scopus2-s2.0-85125061786en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage239en_US
dc.identifier.urihttps://doi.org/10.22038/IJBMS.2022.59713.13243
dc.identifier.urihttps://hdl.handle.net/11616/100497
dc.identifier.volume25en_US
dc.identifier.wosWOS:000754918700006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofIranian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcinetobacter baumanniien_US
dc.subjectInfection control measuresen_US
dc.subjectIntensive care units mcr-2en_US
dc.subjectOral colonizationen_US
dc.titleOral colonization of Acinetobacter baumannii in intensive care units: Risk factors, incidence, molecular epidemiology, association with the occur of pneumonia and sepsis, and infection control measuresen_US
dc.typeArticleen_US

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