Neurological autoantibodies in drug-resistant epilepsy of unknown cause

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dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridKamisli, Suat/0000-0003-4281-3301
dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authoridTecellioglu, Mehmet/0000-0002-8381-9630
dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authorwosidKamisli, Ozden/AAA-6553-2020
dc.authorwosidKamisli, Suat/AAC-2706-2021
dc.authorwosidKamisli, Suat/JVN-4663-2024
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.authorwosidTecellioglu, Mehmet/AAA-3220-2021
dc.authorwosidKamisli, Ozden/JVZ-0145-2024
dc.contributor.authorTecellioglu, Mehmet
dc.contributor.authorKamisli, Ozden
dc.contributor.authorKamisli, Suat
dc.contributor.authorYucel, Fatma Ebru
dc.contributor.authorOzcan, Cemal
dc.date.accessioned2024-08-04T20:44:20Z
dc.date.available2024-08-04T20:44:20Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgroundAutoimmune epilepsy is a rarely diagnosed condition. Recognition of the underlying autoimmune condition is important, as these patients can be resistant to antiepileptic drugs.AimsTo determine the autoimmune and oncological antibodies in adult drug-resistant epilepsy of unknown cause and identify the clinical, radiological, and EEG findings associated with these antibodies according to data in the literature.MethodsEighty-two patients with drug-resistant epilepsy of unknown cause were prospectively identified. Clinical features were recorded. The levels of anti-voltage-gated potassium channel complex (anti-VGKCc), anti-thyroid peroxidase (anti-TPO), anti-nuclear antibody (ANA), anti-glutamic acid decarboxylase (anti-GAD), anti-phospholipid IgG and IgM, anti-cardiolipin IgG and IgM, and onconeural antibodies were determined.ResultsSerum antibody positivity suggesting the potential role of autoimmunity in the aetiology was present in 17 patients with resistant epilepsy (22.0%). Multiple antibodies were found in two patients (2.6%). One of these patients (1.3%) had anti-VGKCc and ANA, whereas another (1.3%) had anti-VGKCc and anti-TPO. A single antibody was present in 15 patients (19.5%). Of the 77 patients finally included in the study, 4 had anti-TPO (5.2%), 1 had anti-GAD (1.3%), 4 had anti-VGKCc (5.2%) 8 had ANA (10.3%), and 2 had onconeural antibodies (2.6%) (1 patient had anti-Yo and 1 had anti-MA2/TA). The other antibodies investigated were not detected. EEG abnormality (focal), focal seizure incidence, and frequent seizures were more common in antibody-positive patients.ConclusionAutoimmune factors may be aetiologically relevant in patients with drug-resistant epilepsy of unknown cause, especially if focal seizures are present together with focal EEG abnormality and frequent seizures.en_US
dc.description.sponsorshipInonu University Scientific Project Unit [2016-64]en_US
dc.description.sponsorshipThis study was supported by the Inonu University Scientific Project Unit (Project no. 2016-64).en_US
dc.identifier.doi10.1007/s11845-018-1777-2
dc.identifier.endpage1063en_US
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.issue4en_US
dc.identifier.pmid29524102en_US
dc.identifier.scopus2-s2.0-85043358009en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1057en_US
dc.identifier.urihttps://doi.org/10.1007/s11845-018-1777-2
dc.identifier.urihttps://hdl.handle.net/11616/98187
dc.identifier.volume187en_US
dc.identifier.wosWOS:000449322500028en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofIrish Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutoimmune epilepsyen_US
dc.subjectDrug-resistant epilepsyen_US
dc.subjectEpilepsyen_US
dc.subjectNeuronal autoantibodiesen_US
dc.titleNeurological autoantibodies in drug-resistant epilepsy of unknown causeen_US
dc.typeArticleen_US

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