Altered isotope charge distribution of acetylcholine neurotransmitter and Myasthenia Gravis

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dc.authoridALTIN, Serdar/0000-0002-4590-907X
dc.authoridBulut, Fatih/0000-0001-6603-2468
dc.authoridDayanc, Baris Emre/0000-0001-7922-1778
dc.authoridUNAL, SERHAT/0000-0003-1184-4711;
dc.authorwosidALTIN, Serdar/H-4880-2014
dc.authorwosidBulut, Fatih/F-7201-2013
dc.authorwosidDayanc, Baris Emre/L-2267-2019
dc.authorwosidUNAL, SERHAT/I-9034-2013
dc.authorwosidbayri, ali/AAA-5966-2021
dc.contributor.authorBayri, A.
dc.contributor.authorUnal, S.
dc.contributor.authorAltin, S.
dc.contributor.authorBulut, F.
dc.contributor.authorDayanc, B. E.
dc.date.accessioned2024-08-04T20:41:36Z
dc.date.available2024-08-04T20:41:36Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAcetylcholine (ACh) is a central neurotransmitter that is used for signal transmission among neurons. For signal transmission in neurons, a neurotransmitter must bind to its receptor in order to produce an action potential. It is known that in Myasthenia Gravis (MG) cases, autoantibodies could block this binding. In the future, the treatment of MG could be achieved via modulation of molecular interaction between ACh and acetylcholine receptor (AChR). This study suggests that if an atom on a ligand (i.e. a neurotransmitter) is replaced with its isotope, it may cause charge redistribution such as that the binding between ligand and its receptor may be improved. Hence suggesting that with replacement of atoms with their isotopes in any biologically important ligand could alter its affinity towards its corresponding receptor, which would have a wide array of applications in medicine. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipIUBAP (Inonu University Scientific Research Council) [2012/38, 2015/52, 2015/97]en_US
dc.description.sponsorshipThis study was supported by IUBAP (Inonu University Scientific Research Council) under grant nos. 2012/38, 2015/52 and 2015/97. The authors would like to thank Dr. H. Kahraman for valuable discussion of ACh and its microenvironment. Prof. Dr. A. Bayri would like to special thank to Dr. F. Isik who performed the Gaussian calculations in his lab. The authors would like to thank Mr. Erdinc Oz for his help on the preparation of the manuscript.en_US
dc.identifier.doi10.1016/j.mehy.2016.01.019
dc.identifier.endpage88en_US
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.pmid26968916en_US
dc.identifier.scopus2-s2.0-84960094231en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage84en_US
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2016.01.019
dc.identifier.urihttps://hdl.handle.net/11616/97213
dc.identifier.volume89en_US
dc.identifier.wosWOS:000372940000019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofMedical Hypothesesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDensity-Functional Theoryen_US
dc.subjectHydrogenen_US
dc.subjectTemperaturesen_US
dc.subjectAntibodiesen_US
dc.subjectPhaseen_US
dc.subjectRisken_US
dc.titleAltered isotope charge distribution of acetylcholine neurotransmitter and Myasthenia Gravisen_US
dc.typeArticleen_US

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