Investigation of the effects of metal oxide nanoparticle mixtures on Danio rerio and Xenopus laevis embryos

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dc.authoridturhan, duygu ozhan/0000-0002-7111-4289
dc.authorwosidOZMEN, MURAT/A-4874-2009
dc.authorwosidturhan, duygu ozhan/AAA-3247-2021
dc.contributor.authorOzmen, Nesrin
dc.contributor.authorTurhan, Duygu Ozhan
dc.contributor.authorGungordu, Abbas
dc.contributor.authorYilmaz, Hatice Caglar
dc.contributor.authorOzmen, Murat
dc.date.accessioned2024-08-04T20:53:18Z
dc.date.available2024-08-04T20:53:18Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the toxic effects of single TiO2, ZnO and Fe2O3 nanoparticles (NPs) and their binary and ternary combinations on the embryonic development of Xenopus laevis and Danio rerio were evaluated. It was aimed to determine the median lethal concentrations, growth retardation and developmental malformation effects and the effects of mixed nanoparticle exposure to selected enzyme biomarkers resulting from the exposure of embryos to NPs. The results showed that ZnO NPs, which are the most toxic according to the highest lethality level, cause developmental delay and malformations. The Fe2O3 and TiO2 NPs caused growth retardation only in D. rerio embryos. It was determined that double and triple combinations of NPs did not cause significant lethality in both species. Biochemical markers showed that mixed NPs could lead to greater toxicity compared to single exposures. The results also revealed that TiO2 or Fe2O3 NPs caused an increase in toxicity when co-existing with ZnO NP due to additive effects. Overall, the results showed that D. rerio was more susceptible to NP exposure in terms of growth and mortality than X. laevis. However, studies that are more comprehensive are needed to better understand the toxicity mechanism of metal oxide NP mixtures.en_US
dc.identifier.doi10.1080/02757540.2022.2162893
dc.identifier.endpage234en_US
dc.identifier.issn0275-7540
dc.identifier.issn1029-0370
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85145464385en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage215en_US
dc.identifier.urihttps://doi.org/10.1080/02757540.2022.2162893
dc.identifier.urihttps://hdl.handle.net/11616/101094
dc.identifier.volume39en_US
dc.identifier.wosWOS:000906352200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofChemistry and Ecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNanoparticle mixtureen_US
dc.subjectzinc oxideen_US
dc.subjectiron (III) oxideen_US
dc.subjecttitanium dioxideen_US
dc.subjecttoxicityen_US
dc.subjectbiomarkeren_US
dc.titleInvestigation of the effects of metal oxide nanoparticle mixtures on Danio rerio and Xenopus laevis embryosen_US
dc.typeArticleen_US

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