Toxic effects of systemic cisplatin on rat eyes and the protective effect of hesperidin against this toxicity

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dc.authoridPolat, Nihat/0000-0002-1735-1363
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidPolat, Nihat/ABI-7316-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidYilmaz, Turgut/S-1198-2017
dc.contributor.authorPolat, Nihat
dc.contributor.authorCiftci, Osman
dc.contributor.authorCetin, Asli
dc.contributor.authorYilmaz, Turgut
dc.date.accessioned2024-08-04T20:41:27Z
dc.date.available2024-08-04T20:41:27Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractContext: In the present study, cisplatin (CP) induced eye toxicity and the beneficial effect of hesperidin (HP) was investigated.Methods: Twenty-eight rats were equally divided into four groups; the first group was kept as control. In the second and third group, CP and HP were given at the doses of 7mg/kg and 50mg/kg/d, respectively. In the fourth group, CP and HP were given together at the same doses. Tissue samples were collected on day 14 of CP treatment.Results: The results demonstrated that CP caused a significant increase in thiobarbituric acid reactive substances (TBARS) levels and decrease of glutathione levels and antioxidant enzyme activity (catalase, superoxide dismutase and glutathione peroxidase) in eye tissues compared to other groups, HP prevented these effects of CP. Besides, CP led to histopathological damage in the retina and cornea. On the other hand, HP treatment prevented histopathological effects of CP.Conclusion: CP had severe dose-limiting toxic effects and HP treatment can be beneficial against the toxic ocular effects of CP. Thus, it appears that co-administration of HP with CP may be a useful approach to attenuate the negative effects of CP on the eye.en_US
dc.identifier.doi10.3109/15569527.2014.999080
dc.identifier.endpage7en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue1en_US
dc.identifier.pmid25594252en_US
dc.identifier.scopus2-s2.0-84955129916en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.3109/15569527.2014.999080
dc.identifier.urihttps://hdl.handle.net/11616/97131
dc.identifier.volume35en_US
dc.identifier.wosWOS:000368640700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous and Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjecthesperidinen_US
dc.subjectoxidative damageen_US
dc.subjectretinotoxicityen_US
dc.titleToxic effects of systemic cisplatin on rat eyes and the protective effect of hesperidin against this toxicityen_US
dc.typeArticleen_US

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