Oxidative Stress in the in vivo DMBA Rat Model of Breast Cancer: Suppression by a Voltage-gated Sodium Channel Inhibitor (RS100642)

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dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridYucel, Neslihan/0000-0001-5845-2614
dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridUyumlu, Ayşe Burçin/0000-0001-9517-9274
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.authorwosidSatilmis, Basri/JBR-9078-2023
dc.authorwosidYucel, Neslihan/ABI-3412-2020
dc.authorwosidSatilmis, Basri/C-5176-2019
dc.authorwosidDjamgoz, Mustafa/KJL-8515-2024
dc.authorwosidUyumlu, Ayşe Burçin/ABH-5573-2020
dc.contributor.authorBatcioglu, Kadir
dc.contributor.authorUyumlu, A. Burcin
dc.contributor.authorSatilmis, Basri
dc.contributor.authorYildirim, Battal
dc.contributor.authorYucel, Neslihan
dc.contributor.authorDemirtas, Hakan
dc.contributor.authorOnkal, Rustem
dc.date.accessioned2024-08-04T20:36:01Z
dc.date.available2024-08-04T20:36:01Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBreast cancer (BCa) was induced in vivo in female rats with 7,12-dimethylbenz(a)anthracene (DMBA). Two main questions were addressed. Firstly, would the carcinogenesis be accompanied by oxidative stress as signalled by superoxide dismutase, glutathione peroxidase, malondialdehyde and total nitrate? Secondly, would treating the rats additionally with a blocker of voltage-gated sodium channel (VGSC) activity, shown previously to promote BCa progression, affect the oxidative responses? The DMBA-induced increases in the antioxidant systems were completely blocked by the VGSC inhibitor RS100642, which also significantly prolonged the lifespan. We conclude that VGSC inhibition in vivo can significantly protect against oxidative stress and improve survival from tumour burden.en_US
dc.description.sponsorshipScientific Research Coordination Department of Inonu University; Pro Cancer Research Fund (PCRF)en_US
dc.description.sponsorshipThis project was supported by a grant from the Scientific Research Coordination Department of Inonu University. The work on 'ion channels and cancer' at Imperial College London is supported by the Pro Cancer Research Fund (PCRF).en_US
dc.identifier.doi10.1111/j.1742-7843.2012.00880.x
dc.identifier.endpage141en_US
dc.identifier.issn1742-7835
dc.identifier.issn1742-7843
dc.identifier.issue2en_US
dc.identifier.pmid22429688en_US
dc.identifier.scopus2-s2.0-84864006656en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.1111/j.1742-7843.2012.00880.x
dc.identifier.urihttps://hdl.handle.net/11616/95727
dc.identifier.volume111en_US
dc.identifier.wosWOS:000306401600012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNitric-Oxideen_US
dc.subjectIon Channelsen_US
dc.subjectMolecular-Mechanismsen_US
dc.subjectMammary-Tumorsen_US
dc.subjectNa+ Channelsen_US
dc.subjectCell-Linesen_US
dc.subjectExpressionen_US
dc.subjectNeuroprotectionen_US
dc.subjectBlockersen_US
dc.titleOxidative Stress in the in vivo DMBA Rat Model of Breast Cancer: Suppression by a Voltage-gated Sodium Channel Inhibitor (RS100642)en_US
dc.typeArticleen_US

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