The mechanical or electrical induction of medullary angiogenesis will it improve sternal wound healing

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dc.authorid143435en_US
dc.authorid138907en_US
dc.authorid38728en_US
dc.authorid52908en_US
dc.contributor.authorAlat, İlker
dc.contributor.authorİnan, Muharrem
dc.contributor.authorGürses, İclal
dc.contributor.authorKekilli, Ersoy
dc.contributor.authorGermen, Burak
dc.contributor.authorHarma, Ahmet
dc.contributor.authorEskin, Ahmet
dc.contributor.authorAyın, Ömer Murat
dc.date.accessioned2017-06-05T08:27:45Z
dc.date.available2017-06-05T08:27:45Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.descriptionTexas Heart Institute Journalen_US
dc.description.abstractWe induced angiogenesis in the tibial medulla and cortex of rabbits by electrical and mechanical stimulation, with the aim of future application to ischemic disease. Sixteen New Zealand rabbits were divided into 4 groups: in Group 1, a K wire was inserted into the medullary channel; in Group 2, a hole was drilled into the tibia; in Group 3, electrical stimulation was applied to the medullary channel; and in Group 4 (the control group), nothing was done. The interventions were applied during a 21-day period, after which all animals were evaluated scintigraphically and histopathologically. All 3 interventional groups were significantly superior to the control group in regard to medullary and cortical vascularity: the P values were 0.021 in all comparisons to control. However, the most fibrotic changes in the medulla occurred in the group that had been treated with electricity (P=0.008). Slight fibrotic changes occurred in the hole group (P=0.040), and none occurred in the K-wire group. In sum, all 3 interventions are capable of inducing medullary angiogenesis, but electricity is inferior in regard to fibrotic change. We believe that this present study can establish a baseline for further work that explores clinical applications to problematic ischemic conditions, including delayed sternal wound healing after cardiac surgery.en_US
dc.identifier.citationAlat, İ., İnan, M., Gürses, İ., Kekilli, E., Germen, B., Harma, A., … Aydın, Ö. M. (2004). The Mechanical Or Electrical İnduction Of Medullary Angiogenesis Will İt İmprove Sternal Wound Healing . Tex Heart Inst J, (31), 363–367.en_US
dc.identifier.endpage367en_US
dc.identifier.issue0en_US
dc.identifier.startpage363en_US
dc.identifier.urihttps://hdl.handle.net/11616/7050
dc.identifier.volume31en_US
dc.language.isotren_US
dc.publisherTex Heart Inst Jen_US
dc.relation.ispartofTex Heart Inst Jen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectBone regenerationen_US
dc.subjectElectric stimulation therapyen_US
dc.subjectNeovascularizationen_US
dc.subjectPhysiologicen_US
dc.subjectSternum/blood supplyen_US
dc.titleThe mechanical or electrical induction of medullary angiogenesis will it improve sternal wound healingen_US
dc.typeArticleen_US

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