Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı Koleksiyonu
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Öğe Problems encountered in screening study with ultrasound for early diagnosis of developmental dysplasia of hip in eastern region of Turkey(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Ceylan, Mehmet Fethi; Korkmaz, Mehmet FatihThe aim of this study is to evaluate results of the screening program of the development al dysplasia of the hip (DDH) examined in newborn period. The problems encountered in the applicability of the early screening program were e valuated. By interviewing with the family of 1680 newborns born in our institution or referred, the information was given about the DDH and its risk factors, obtained results were recorded. The families were told to bring their babies for examination and hip ultrasound at the 3rd or 4th week of birth. In addition, all the parents were called by telephone the day prior to their appointments. Five hundred and thirty-six babies (31.3%) were brought to the first appointment. Forty-two hips (3.9%) of the 30 infants (5.6%) were detected as dislocated (Type 2c, D, 3). The 8 of these 30 patients (26.7%) whom the treatment was started were brought for the second control. Asymmetry of thigh folds was positive in the highest rate as the finding of the examination in the infants brought to the appointment. The rate of swaddling at the first appointment was found to be 74.2%. Surprisingly, less than one third of children were brought to ultrasound examination at first control. Similarly, about 3/4 of the parents continued to use swaddling for their babies. For the success of national DDH screening program, additional precautions must be taken to ensure the participation of the families and re lease of the swaddling.Öğe Mini open surgical treatment of knee septic arthritis with local anesthesia: a prospective preliminary report(DERMAN MEDICAL PUBL, KARTALTEPE MAHALLESI, ATATURK BULVARI, ANKARA, 00000, TURKEY, 2018) Ceylan, Mehmet FethiAim: Good pain management is provided via spinal and general anesthesia during knee joint drainage to treat septic arthritis, but the side effects are greater than those associated with local anesthesia, and the preparation process is long. Arthroscopic drainage under local anesthesia for knee septic arthritis treatment have been described, but this method requires special equipment. In this study, we aimed to evaluate the applicability of mini-open surgery under local anesthetic infiltration in cases of septic knee arthritis. Material and Method: 14 consecutive patients (eight men, six women) were admitted for knee septic arthritis treatment. Patient age ranged from 18 to 56 years, with an average age of 33 years. Drainage procedure was performed under local anesthesia, and the results were evaluated clinically. Results: The visual analog scale scores were between two and four (mean 2.8). The follow-up period was 10-21 months (mean 14.3). The Tegner and International Knee Documentation Committee scores were acceptable except for one patient. Discussion: This prospective study included mini-open surgery performed under local anesthesia on 14 septic knees, and showed that this method is safe, effective, well tolerated and be alternative to conventional techniques.Öğe Mid-term outcomes of arthroscopic treatment in patients with a stiff elbow(CUREUS INC, PO BOX 61002, PALO ALTO, CA 94306 USA, 2018) Sevimli, Reşit; Aslanturk, Okan; Ergen, Emre; Ertem, KadirIntroduction Loss of function and pain are the main complaints at the time of hospital admission for patients with a stiff elbow. In this study, we present mid-term radiological and functional results for the use of the arthroscopic release technique in patients admitted to the outpatient clinic with a stiff elbow. Methods A total of 22 patients (six females, 16 males; mean age: 36 years, range: 18 to 56 years) who underwent an arthroscopic intervention for traumatic or non-traumatic stiff elbow and arthrosis between January 2005 and November 2015 were included in the study. All patients started elbow movement after the first day following surgery. Pre- and postoperative radiological evaluations of patients were carried out, in addition to functional evaluation to measure the range of motion of the elbow joint and the Disabilities of the Arm, Shoulder and Hand (DASH) scores before and after surgery. Results The mean follow-up was 28.4 (range: 21 to 118) months. The mean preoperative flexion-extension arc of the patients was 89 degrees (range: 0 degrees to 115 degrees), and the mean flexion-extension arc increased to 103.5 degrees (range: 52 degrees to 128 degrees) at the final follow-up visit (p < 0.05). The mean preoperative DASH score was 42.17 (range: 33 to 81), decreasing to 30.35 (range: 9.7 to 41.3) postoperatively (p<0.05). In the final visit, none of the patients were found to require additional surgical interventions for the elbow. Conclusions Arthroscopic release can be considered a safe and effective option to obtain range of motion in joints in post-traumatic stiff elbow cases.Öğe Investigation of the presence of pantone-valentine leukocidin in staphylococcus aureus strainsısolated from orthopedic surgical site ınfections(ANKARA MICROBIOLOGY SOC, HACETLEPE UNIV FACULTY MEDICINE DEPT MICROBIOLOGY, 06100 ANKARA, TURKEY, 2018) Duman, Yücel; Sevimli, ReşitStaphylococcus aureus is one of the most clinically important bacteria causing infection in humans. It is an important pathogen in surgical site infections (SSIs), especially after orthopedic surgery. Pantone-valentine leukocidin (PVL) has a great importance in the virulence of S.aureus because it can destroy polymorphonuclear cells by necrosis or apoptosis. The spread of PVL positive S.aureus is a great concern, since it may become an important factor for increased morbidity and mortality in SSIs, especially after surgery. In this study, we aimed to investigate the presence of PVL in S.aureus strains isolated from patients who had surgical site infections after orthopedic surgery, and also the clinical status of these patients. Between 2013 and 2017, 101 patients who had SSIs due to S.aureus after orthopedic surgery were included in the study. Identification of the strains was determined by conventional methods and "Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry" (MALDI-TOF MS). Methicillin resistance was determined by Kirby-Bauer disc diffusion method and automated system (Vitek 2, bioMerieux, France). The PVL gene region was investigated by polymerase chain reaction (PCR) method by using the primers Luk-PV-1 and Luk-PV-2. The duration of the patients' hospitalization, C-reactive protein (CRP) and sedimentation levels and clinical status were obtained from the hospital information system, retrospectively. Fifteen (14.9%) of the isolates were methicillin resistance S.aureus (MRSA) and 86 (85.1%) were methicillin susceptibility S.aureus (MSSA). PVL positivity was detected in 14 (13.9%) isolates (3 MRSA, 11 MSSA). The mean hospital stays in PVL-negative patients were 17 (5-73) days and 46 (21-103) days in PVL-positive patients. It was observed that the serologic markers CRP and sedimentation were between 5-7 and 40-60 in PVL negative patients, and between 11-20 and 90-110 in PVL positive patients, respectively. In PVL-negative patients, serologic markers improved in 7-10 days, while in PVL-positive patients they were improved in 17-32 days. Osteomyelitis occurred in six patients (2 PVL positive MRSA, 1 PVL positive MSSA and 3 PVL negative MRSA). In two of the patients who have developed osteomyelitis with PVL-positive MRSA, PVL gene positive S.aureus isolates were observed in their orthopedic SSIs. We also determined that these isolates increased the hospitalization days, improvement time of serological markers and mortality. It is worrisome to isolate PVL-positive S.aureus strains in SSIs. Therefore, we believe that it would be useful to take infection control measures to prevent the spread of these strains in the hospital setting.Öğe Extensor carpi radialis longus tendon ball interposition arthroplasty for treatment of late-stagekienbock's disease: short-term results of a novel technique(Sage publıcatıons ınc, 2455 teller rd, thousand oaks, ca 91320 usa, 2018) Aslanturk, Okan; Ertem, Kadir; Ergen, Emre; Koroglu, MuhammedPurpose:The aim of this study was to evaluate short-term clinical and radiological results of extensor carpi radialis longus (ECRL) tendon ball arthroplasty for treatment of late-stage Kienbock's disease. Methods: We retrospectively reviewed data of 19 patients suffering from Kienbock's treated with ECRL tendon ball arthroplasty between December 2014 and December 2016. Patients' clinical functions were assessed using grip strength, range of motion (ROM) of the wrist, QuickDASH, Mayo wrist score, and visual analog scale score. Radiological examination was performed to assess carpal height ratio and progression of arthritis. Results: The median follow-up was 30 months (range, 12-36 months). At final follow-up, ROM of operated wrist was 71% of the nonoperated side. Thirteen (86.6%) patients were pain free. Carpal height ratio was statistically significantly reduced compared with preoperative values. All patients declared their satisfaction with the results due to their preoperatiÖğe Do the trace elements play a role in the etiopathogenesis of developmental dysplasia of hip?(Verducı publısher, vıa gregorıo vıı, rome, 186-00165, ıtaly, 2018) Guner, S.; Guner, SI; Gokalp, MA; Ceylan, MF; Unsal, SS; Demir, HOBJECTIVE: Alterations in the connective tissue of the hip joint capsule and ligaments might account for the increased laxity seen in patients with developmental dysplasia of the hip. The tensile features of the connective tissue depend on collagen. A number of prior studies have noted the association between the trace elements and collagen biosynthesis. The aim of this research is to determine whether there exists an association between the trace elements and developmental dysplasia of the hip. PATIENTS AND METHODS: This investigation included 27 patients with developmental dysplasia of the hip (18 females and nine males; mean age 24.3 +/- 6.3 months, range 18-36 months) and 26 healthy controls (15 females and 11 males; mean age 23.8 +/- 5.4 months, range 18-36 months). The levels of the serum trace elements in the groups were statistically compared. RESULTS: The Cu levels of the patients with developmental dysplasia of hip were statistically higher than those of the control group (p<0.05). The Zn, Fe, Mg, and Mn levels of the patients with developmental dysplasia of hip were statistically lower than those of the control group (p<0.05). CONCLUSIONS: We found an association between developmental dysplasia of the hip and the serum trace element levels. We, therefore, believe that the trace element levels may shed light on the etiopathogenesis of developmental dysplasia of the hip. This work should be supported by future studies concerning the causes of the alterations in the serum trace element levels seen in patients with developmental dysplasia of the hipÖğe Criteria for Ending the Distal Fusion at the L3 Vertebra vs. L4 in Surgical Treatment of Adolescent Idiopathic Scoliosis Patients with Lenke Type 3C, 5C, and 6C Curves: Results After Ten Years of Follow-up(CUREUS INC, PO BOX 61002, PALO ALTO, CA 94306 USA, 2018) Korkmaz, Mehmet FatihIntroduction The selection of the most distal caudal vertebra in spinal fusion surgeries in adolescent idiopathic scoliosis patients with structural lumbar curvatures is still a matter of debate. The aim of this study was to determine the preoperative radiological criteria on the traction X-rays under general anesthesia (TrUGA) for selection between the L3 and L4 vertebrae and to assess the efficacy of these criteria via the long-term results of patients with Lenke Type 3C, 5C, and 6C curves. Methods Radiological data of 93 patients (84 females, 9 males) who met the inclusion criteria were retrospectively evaluated. The relationship between the L3 vertebra and the central sacral vertebral line, the portion of the L3 vertebra in the stable zone of Harrington, the parallelism of the L3 with the sacrum, and the tilt and rotation of the L3 on TrUGA radiographs were evaluated for the selection of the lowest instrumented vertebrae (LIV). Clinical results were analyzed using the Scoliosis Research Society-22 (SRS-22) questionnaire. Results The mean follow-up period of the study group was 149.3 months. According to the Lenke classification, 29 patients had Type 3C, 33 had Type SC, and 31 had Type 6C curves. The preoperative analysis was based on standing anteroposterior (AP), supine traction, and bending X-rays, and the L3 vertebra was selected as the LIV in 37 patients (40%). These X-rays suggested IA as the LIV in 56 patients (60%); however, based on our study criteria, the L3 vertebra was selected. No significant loss of correction was observed nor additional surgery due to decompensation was required in the follow-up period. Conclusion The use of TrUGA radiographs with the identified criteria is an efficient alternative method in the selection of the LIV in patients with Lenke Type 3C, 5C, and 6C curves.Öğe Determining the optimal length and safety of pedicle screws in the t12 vertebra: a morphometricstudy(Cureus ınc, po box 61002, palo alto, ca 94306 usa, 2018) Korkmaz, Mehmet F.; Erdem, Mehmet N.; Ozevren, Huseyin; Sevimli, ResitIntroduction: Despite the developments in implant technology and imaging methods and the advances in surgical techniques, there are still potential problems and complications of transpedicular screw application. This is a morphometric study to examine the proximity of the T12 vertebra to the thoracic aorta. Our aim was to define the appropriate length of the pedicle screw to be used in the 12 th thoracic vertebra, using computed tomography (CT) data. Methods: Randomly selected cases from the same ethnic group in a specific age group were examined in terms of the length from the anterior vertebral body and the screw entry point of the T12 vertebra to the thoracic aorta. In light of these data, a statistical analysis was made for the selection of the most appropriate screw length. Results: A statistically significant difference was detected in the distance from the T12 left screw entry point to the aorta between males and females (p=0.001). No statistically significant correlation was found between age and the distance between the left screw entry point and the aorta (p=0.105). Also, no statistically significant difference was detected between the T12 vertebral body-aorta distance in males and in females (p=0.212). The relationship between the shortest aorta-vertebral body distance and age was not statistically significant (p=0.7). Similarly, there was no statistically significant difference between the left screw entry pointaorta distance and the aorta-vertebral body shortest distance (p=0.731). Conclusions: Significant differences were observed between males and females in terms of the distance between the T12 vertebra left screw entry point and the thoracic aorta (p=0.001). Thus, we can assert the need for the preoperative evaluation of patients with computed tomography in selecting the appropriate screw length and avoiding complications.Öğe Analysis of orthopedic surgery of patients with metastatic bone tumors and pathological fractures(SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND, 2018) Sevimli, Reşit; Korkmaz, Mehmet FatihObjective This study was performed to determine the most common causes, locations, and treatments of metastasizing primary tumors through evaluation of patients with metastatic bone tumors who were admitted to our clinic. Methods In total, 96 patients with metastatic bone tumors who were admitted to our clinic from 2000 to 2016 were included in the study. Results The breast (30 patients, 31.3%) and lung (18 patients, 18.8%) were the most commonly metastasized primary organs. The femur was the most commonly metastasized bone. Conclusions Bone tumors in patients of advanced age are, unless otherwise proven, considered to be metastatic, and the development of specific diagnostic and treatment algorithms is needed. Clinicians should attempt to improve the general condition of patients with tumors exhibiting bone metastasis to increase the patients' quality of life by providing early mobilization. Thus, appropriate patient selection and proper internal fixation are essential.Öğe Endoscopic assisted retrograde release of posterior interosseous nerve: Preliminary results of a new technique(Journal of plastıc reconstructıve and aesthetıc surgery, 2018) Ertem, Kadir; Aslanturk, Okan; Ergen, Emre; Karakaplan, Mustafa; Canbay, AliÖğe The mechanical or electrical induction of medullary angiogenesis will it improve sternal wound healing(Tex Heart Inst J, 2004) Alat, İlker; İnan, Muharrem; Gürses, İclal; Kekilli, Ersoy; Germen, Burak; Harma, Ahmet; Eskin, Ahmet; Ayın, Ömer MuratWe induced angiogenesis in the tibial medulla and cortex of rabbits by electrical and mechanical stimulation, with the aim of future application to ischemic disease. Sixteen New Zealand rabbits were divided into 4 groups: in Group 1, a K wire was inserted into the medullary channel; in Group 2, a hole was drilled into the tibia; in Group 3, electrical stimulation was applied to the medullary channel; and in Group 4 (the control group), nothing was done. The interventions were applied during a 21-day period, after which all animals were evaluated scintigraphically and histopathologically. All 3 interventional groups were significantly superior to the control group in regard to medullary and cortical vascularity: the P values were 0.021 in all comparisons to control. However, the most fibrotic changes in the medulla occurred in the group that had been treated with electricity (P=0.008). Slight fibrotic changes occurred in the hole group (P=0.040), and none occurred in the K-wire group. In sum, all 3 interventions are capable of inducing medullary angiogenesis, but electricity is inferior in regard to fibrotic change. We believe that this present study can establish a baseline for further work that explores clinical applications to problematic ischemic conditions, including delayed sternal wound healing after cardiac surgery.Öğe Emergency pelvic external stabilization as the first step treatment in high risk pelvic fractures(Ulus Travma Acil Cerrahi Derg, 2004) Harma, Ahmet; İnan, MuharremÖğe A comparison between the use of a monolateral external fixator and the Ilizarov technique for pelvic support osteotomies(Acta Orthop Traumatol Turc, 2004) İnan, Muharrem; Küçükkaya, Metin; Harma, AhmetÖğe The mechanical or electrical induction of medullary angiogenesis will it improve sternal wound healing(Tex Heart Inst J, 2004) Alat, İlker; İnan, Muharrem; Gürses, İclal; Kekilli, Ersoy; Germen, Burak; Harma, Ahmet; Eskin, Ahmet; Aydın, Ömer MuratWe induced angiogenesis in the tibial medulla and cortex of rabbits by electrical and mechanical stimulation, with the aim of future application to ischemic disease. Sixteen New Zealand rabbits were divided into 4 groups: in Group 1, a K wire was inserted into the medullary channel; in Group 2, a hole was drilled into the tibia; in Group 3, electrical stimulation was applied to the medullary channel; and in Group 4 (the control group), nothing was done. The interventions were applied during a 21-day period, after which all animals were evaluated scintigraphically and histopathologically. All 3 interventional groups were significantly superior to the control group in regard to medullary and cortical vascularity: the P values were 0.021 in all comparisons to control. However, the most fibrotic changes in the medulla occurred in the group that had been treated with electricity (P=0.008). Slight fibrotic changes occurred in the hole group (P=0.040), and none occurred in the K-wire group. In sum, all 3 interventions are capable of inducing medullary angiogenesis, but electricity is inferior in regard to fibrotic change. We believe that this present study can establish a baseline for further work that explores clinical applications to problematic ischemic conditions, including delayed sternal wound healing after cardiac surgery. (Tex Heart Inst J 2004;31:363-7)Öğe Radial artery pellet embolism a case report(Ulus Travma Acil Cerrahi Derg, 2004) Ertem, Kadir; Ayan, İrfan; Harma, Ahmet; Türköz, Rıza; Bora, ArslanA fifty-four-year-old male patient presented to our emergency department with a gunshot injury in his arm, caused by pellets. Surgical exploration showed injury to the brachial artery, which was then repaired with a saphenous vein graft. Conservative treatment was planned for associated nerve injuries. After arterial flow began, two pellet-like solid bodies were palpated in the radial artery trace at the wrist level and the pellets were removed from the lumen of the artery. Ten days after surgery, the patient had profuse bleeding in the arm. On exploration, partial necrosis was detected in the saphenous vein graft and primary repair was performed. H o w e v e r, on the 19th day, the bleeding recurred and increased necrosis and rupture of the artery, 2-3 cm in size, were detected. Arterial repair was repeated with another saphenous vein graft from the other limb. The patient returned to normal daily activities nine months after the injury, with slight cold intolerance. Clinical examination and Doppler studies did not show any signs of vascular deficiency. Arterial or venous pellet embolism should be included in the evaluation of patients with gunshot injuries.Öğe Surgical management of transforaminal sacral fractures(International Orthopaedics, 2005) Harma, Ahmet; İnan, MuharremAbstract Fourteen patients with transforaminal sacral fractures were treated with posterior iliosacral instrumentation. Patients were assessed in terms of surgical technique and functional results. A subjective functional scoring with a five-point scale was performed at the last follow-up. Activity pain, pain at rest, limping and patient satisfaction were evaluated. By considering symptom and satisfaction scores, subjective functional assessment revealed that ten patients had excellent results, two good and two moderate. There were no patients with poor functional outcome. The surgical technique is not a new concept. Combining sacral bar and pediculo-iliac fixation methods, provides vertical as well as horizontal stability and allows early weight bearing, the methods has many advantages. However, vertical and horizontal stabilities achieved by this technique may require further assessment with comparative biomechanical studies. Résumé Quatorze malades avec des fractures sacrées transforaminales ont été traités avec une instrumentation iliosacrée postérieure. Les malades ont été étudiés en fonction de la technique chirurgicale, et des résultats fonctionnels. Une échelle fonctionnelle subjective à 5 points a été utilisée au dernier examen. La douleur à l’activité et au repos, la boiterie et la satisfaction des patients ont été évalué. En considérant les symptômes et le score fonctionnel, 10 patients avaient un résultat excellent, 2 un bon résultat et 2 un résultat moyen. Il n’y avait aucun mauvais résultat. La technique chirurgicale n’est pas un nouveau concept. En combinant une barre sacrée et les méthodes de fixation pédiculaires , la stabilité horizontale aussi bien que verticale est obtenue, et une remise en charge précoce est possible. Cependant, les stabilités verticales et horizontales obtenues par cette technique peuvent exiger une appré- ciation supplémentaire avec des études biomécaniques comparatives.Öğe Successful treatment of buerger s disease with ıntramedullary k wire the results of the first 11 extremities(European Journal of Vascular and Endovascular Surgery, 2005) İnan, Muharrem; Alat, İlker; Kutlu, Ramazan; Harma, Ahmet; Germen, BurakObjective. This study describes a new technique for treatment of Buerger’s disease, developed to stimulate angiogenesis, using a Kirschner wire placed in the medullary canal of the tibia. The aim of the study was to evaluate clinical and radiological effects of this technique in patients where medical and surgical therapy had failed. Material and methods. Eleven extremities (six patients) with Buerger’s disease were treated with the intramedullary Kirschner wire technique. Inclusion criteria were chronic critical ischemia, Rutherford Grade II or III, with major arterial occlusion shown by Doppler examination and angiography; failure to respond to non-surgical and surgical treatment; and the need for strong analgesics. Results. The mean follow-up time was 19 months (range, 13–25 months). Satisfactory remission in each patient was obtained within 6 weeks of intervention. A significant improvement in clinical manifestations including reduced rest pain and increased claudication distance was observed. Foot ulcers completely healed after Kirschner wire intervention. Conclusion. Despite short-term follow-up and small patient series, the intramedullary Kirschner wire technique can be expected to achieve relief of pain and a decrease in major amputations in patients with Buerger’s disease in whom medical and surgical therapy had failed. However, comparative studies with longer follow-up should be done to confirm the benefits of this new treatment.Öğe The comparison of femoral curves and curves of contemporary intramedullary nails(Surgical and Radiologic Anatomy, 2005) Harma, Ahmet; Germen, Burak; Karakaş, Hakkı Muammer; Elmalı, Nurzat; İnan, MuharremAbstract The aim of this study was to evaluate both the cortical and the medullary anterior bowing of the femur, and to compare these measurements with current intramedullary nails to assess the adequacy of their design. Methods: Lateral digital radiographic views of left femurs of 104 normal subjects (18–68 years old) were obtained. Radii of cortical and medullary curvatures of femurs were calculated using these images. The values obtained were compared to the radius of curvatures of ten different intramedullary nails. Results: Medullary bowing was between 114 and 1,389 mm (mean: 722 mm, SD: 230 mm) and the cortical bowing was between 109 and 1,666 mm (mean: 770 mm, SD: 267 mm). For males, these values were 114–1,389 mm (mean: 722 mm, SD: 230 mm) and 109–1,666 mm (mean: 770 mm, SD: 267 mm), respectively. For females, they were 114– 1,389 mm (mean: 722 mm, SD: 230 mm) and 109– 1,666 mm (mean: 770 mm, SD: 267 mm), respectively. The differences between genders were not significant. Cortical and medullar bowing was strongly correlated with age (r= 0.269, p<0.006 and r= 0.234, p<0.017, respectively). These significances were produced by females only. Radii of curvatures of intramedullary nails ranged between 150 and 300 cm and were higher than the mean cortical (77 cm) and medullary (72.2 cm) bowings. Conclusion: The difference between the curves of femur and the contemporary femoral nails implicates the inadequacy of the design of such nails for the Caucasian race living in Anatolia. Therefore, such nails should be revised accordingly to prevent the above-mentioned complications.Öğe Effect of resveratrol in experimental osteoarthritis in rabbits(Inflammation Research, 2005) Elmalı, Nurzat; Esenkaya, İrfan; Harma, Ahmet; Ertem, Kadir; Türköz, Rıza; Mızrak, BülentObjective: Resveratrol (trans-3,4¢,5-trihydroxystilbene) is a phytoalexin found in high concentration in the skins of grapes and red wines which has been shown to have antiinflammatory, anticancerogen and antioxidant properties. Resveratrol is a potent and specific inhibitor of nuclear factor kappa B (NF-kB). Resveratrol also inhibits COX-2 gene expressionand enzyme activity. We aimed to determine the in vivo effects of intra-articular injections of resveratrol on cartilage and synovium in an experimental osteoarthritis (OA) model in rabbits. Methods: As OA model, rabbits underwent unilateral anterior cruciate ligament transection (ACLT). Five weeks after test group was injected with 10 mMol/kg resveratrol in dimethylsulphoxide (DMSO) in the knees once daily for two weeks and as the control group at the same time DMSO was injected into the knees. All rabbits were killed one week after the last injection. Cartilage tissue and synovium were evaluated with a histological scoring system. Results: Histological evaluation of cartilage tissue by H&E staining revealed a significantly reduced average cartilage tissue destruction score of 1.7 in the resveratrol group versus 2.8 in the control group (p = 0.016). Loss of matrix proteoglycan content in cartilage was also much lower, as determined by safranin O staining. Scores of synovial inflammation didn’t show difference between groups (1,3 vs 2,2; p = 0.057). Conclusion: A characteristic parameter in arthritis is the progressive loss of articular cartilage. This study suggests that intraarticular injections of resveratrol starting at the onset of disease may protect cartilage against the development of experimentally induced OA.Öğe The factors affecting thermal necrosis secondary to the application of the Ilizarov transosseous wire(Acta Orthop Traumatol Turc, 2005) İnan, Muharrem; Mızrak, Bülent; Ertem, Kadir; Harma, Ahmet; Elmalı, Nurzat; Ayan, İrfanObjectives: We investigated thermal changes associated with the application of the Ilizarov transosseous wires, the extent of necrosis and the factors affecting necrosis. Me t h o d s : We used a pair of tibiae from a 1-year-old cow. After removal of metaphyseal areas, each of four equal diaphyseal zones marked on both tibiae was drilled at 600, 900, 1,200 and 1,800 rpm, each time with a new wire. Heat changes were recorded with heat electrodes during the application and the speed of the wire was calculated. For histopathological examination, specimens were obtained at the access and exit sites to assess the extent of necrosis. Thermal changes between the zones and immediate and remote cortices were compared. The most significant factor affecting the heat changes was analyzed by linear regression. R e s u l t s : Heat changes varied between 48.4 ¡C (at 1,200 rpm) and 151.9 ¡C (at 600 rpm). The thickness of the immediate cortex, the time and speed for the wire to pass the cortex were found as significant parameters in heat changes (p=0.003, p=0.01, and p=0.01, respectively). A negative correlation was found between the speed of the wire and the thickness of the necrotic area (r=-0.901, p=0.001). Regression analysis showed that the time for the wire to pass through the cortex was the most significant factor in inducing heat changes in both cortices (p=0.001, p=0.003, respectively). Histopathologically, the extent of necrosis and bone erosion was associated with lower drill speeds. Necrosis was significantly notable in the immediate cortex than that of the remote one (p=0.006). Conclusion: Transosseous wires should be passed at high drill speeds and with earliest time elapses to reduce thermal necrosis.
