Relationship Between Phenolic Content Determined by LC/MS/MS and Antioxidant Capacity and Enzyme Inhibition of Cyclotrichium niveum L.

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dc.authoridGÜZEL, Abdussamat/0000-0001-7810-4510
dc.authorwosidGUZEL, ABDUSSAMAT/AAI-1866-2019
dc.authorwosidGÜZEL, Abdussamat/GXG-4734-2022
dc.contributor.authorGüzel, Abdussamat
dc.date.accessioned2024-08-04T20:53:31Z
dc.date.available2024-08-04T20:53:31Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCyclotrichium niveum (Boiss.) Manden & Scheng belonging to the Lamiaceae family, which is an endemic species in the eastern Anatolian region of Turkey, has an important place in terms of ethno-botany. The phytochemical composition of the plant, inhibition of acetylcholinesterase (AChE) (which hydrolyzes the neurotransmitter acetylcholine), inhibition of paraoxonase for antiatherosclerotic activity (hPON 1) (which detoxifies organophosphates), and antioxidant capacity of this plant. Phytochemical content was determined by LC/MS/MS, and enzyme inhibition and antioxidant capacity studies were determined by spectrophotometer. Antioxidant capacity of C. niveum extracts (methanol, hexane, and water) was determined by applying ABTS.(+), DPPH., FRAP, and CUPRAC methods. Both the water and the methanol extracts of the C. niveum exhibited significant inhibition on the AChE (IC50 value for methanol and water extract 0.114 +/- 0.14 mg/mL (R2:0.997) and 0.178 +/- 0.12 mg/mL (R-2: 0.994), respectively). In contrast, the methanol and water extracts of the C. niveum did not exhibit the inhibition effect on hPON 1. The highest activity for ABTS.(+) was 66.53 % in the water extract, and DPPH. was 55.03 % in the methanol extract. In the metal-reducing power assay, the absorbance was 0.168 +/- 0.04 for FRAP water extract and 0.621 +/- 0.01 for CUPRAC methanol extract. According to LC/MS/MS analyses, hydroxybenzoic acid, salicylic acid, syringic acid, acetohydroxamic acid and luteolin determined in the plant extract. As a consequence, C. niveum which has antioxidant, anti-atherogenic and anti-neurodegenerative properties has the potential to be used as a natural medication instead of synthetic drugs used in Alzheimer's patients.en_US
dc.identifier.doi10.1002/cbdv.202300027
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue4en_US
dc.identifier.pmid36891984en_US
dc.identifier.scopus2-s2.0-85150278659en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202300027
dc.identifier.urihttps://hdl.handle.net/11616/101228
dc.identifier.volume20en_US
dc.identifier.wosWOS:000953582500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacetylcholinesteraseen_US
dc.subjectantioxidanten_US
dc.subjectCyclotrichium niveumen_US
dc.subjectLCen_US
dc.subjectMSen_US
dc.subjectparaoxonaseen_US
dc.titleRelationship Between Phenolic Content Determined by LC/MS/MS and Antioxidant Capacity and Enzyme Inhibition of Cyclotrichium niveum L.en_US
dc.typeArticleen_US

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