Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary results

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dc.authoridErsoy, Mehmet/0000-0002-0724-2825;
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.authorwosidSağır, Özlem/AAS-5880-2020
dc.contributor.authorKoroglu, A
dc.contributor.authorDemirbilek, S
dc.contributor.authorTeksan, H
dc.contributor.authorSagir, O
dc.contributor.authorBut, AK
dc.contributor.authorErsoy, MO
dc.date.accessioned2024-08-04T20:14:46Z
dc.date.available2024-08-04T20:14:46Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. We evaluated the sedative, haemodynamic and respiratory effects of dexmedetomidine and compared them with those of midazolam in children undergoing magnetic resonance imaging (MRI) procedures. Methods. Eighty children aged between 1 and 7 yr were randomly allocated to receive sedation with either dexmedetomidine (group D, n=40) or midazolam (group M, n=40). The loading dose of the study drugs was administered for 10 min (dexmedetomidine 1 mu g kg(-1) or midazolam 0.2 mg kg(-1)) followed by continuous infusion (dexmedetomidine 0.5 mu g kg(-1) h(-1) or midazolam 6 mu g kg(-1) min(-1)). Inadequate sedation was defined as difficulty in completing the procedure because of the child's movement during MRI. The children who were inadequately sedated were given a single dose of rescue midazolam and/or propofol intravenously. Mean arterial pressure (MAP), heart rate (HR), peripheral oxygen saturation (Sp(o2)) and ventilatory frequency (VF) were monitored and recorded during the study. Results. The quality of MRI was significantly better and the rate of adequate sedation was higher in group D than in group M (P < 0.001). In group D, the requirement for rescue drugs was lower and the onset of sedation time was shorter than in group M (P < 0.001). MAP, HR and VF decreased from baseline during sedation in both groups (P < 0.001). Conclusions. Dexmedetomidine provided adequate sedation in most of the children aged 1-7 yr without haemodynamic or respiratory effects during MRI procedures.en_US
dc.identifier.doi10.1093/bja/aei119
dc.identifier.endpage824en_US
dc.identifier.issn0007-0912
dc.identifier.issn1471-6771
dc.identifier.issue6en_US
dc.identifier.pmid15764627en_US
dc.identifier.scopus2-s2.0-19944386258en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage821en_US
dc.identifier.urihttps://doi.org/10.1093/bja/aei119
dc.identifier.urihttps://hdl.handle.net/11616/93956
dc.identifier.volume94en_US
dc.identifier.wosWOS:000228930700021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofBritish Journal of Anaesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbrain, magnetic resonance imagingen_US
dc.subjectsedation, paediatricsen_US
dc.subjectsedative, dexmedetomidineen_US
dc.titleSedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary resultsen_US
dc.typeArticleen_US

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