Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies

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dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691;
dc.authorwosidCelik, ebru/X-4343-2019
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidYILMAZ, Ercan/AAA-1818-2021
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorCiftci, Osman
dc.contributor.authorKafadar, Yusuf Taner
dc.contributor.authorCelik, Ebru
dc.date.accessioned2024-08-04T20:45:43Z
dc.date.available2024-08-04T20:45:43Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: We investigated the roles of inflammatory cytokines and the A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family in the etiopathogenesis of spontaneous preterm delivery by comparing the ADAMTS4, ADAMTS5, interleukin (IL)-6, and tumor necrosis factor-alpha (TNF-alpha) levels in second-trimester amniotic fluid between pregnant women with preterm birth and term controls. Methods: All pregnant women who underwent second-trimester amniocentesis for genetic analysis between January 1, 2016, and January 1, 2018, were enrolled in this study. From this cohort, 22 patients who subsequently experienced spontaneous preterm delivery before 34 weeks of pregnancy formed the study group, and 22 age- and body mass index (BMI)-matched patients without preterm birth constituted the control group. Results: No significant differences were observed between the preterm birth and control groups in terms of age, BMI, obstetric history of preterm delivery, gestational age at amniocentesis, or indication for amniocentesis. The mean amniotic fluid levels of ADAMTS4 and ADAMTS5 were significantly increased in the preterm birth group compared to the control group (248.3 +/- 22.6 and 182.4 +/- 19.8 pg/mL, P = 0.012; and 198.6 +/- 21.6 and 159.1 +/- 21.7 pg/mL, P = 0.035, respectively). Significantly increased IL-6 and TNF-a levels were also detected in the amniotic fluid of women who experienced spontaneous preterm delivery, relative to controls (142.1 +/- 16.2 and 95.8 +/- 16.4 pg/mL, P < 0.001; and 139.4 +/- 12.5 and 89.6 +/- 11.2 pg/mL, P < 0.001, respectively). Conclusion: The results of this study imply that increased mid-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-alpha play an important role in the pathophysiology of spontaneous preterm delivery.en_US
dc.identifier.doi10.1515/jpm-2018-0297
dc.identifier.endpage310en_US
dc.identifier.issn0300-5577
dc.identifier.issn1619-3997
dc.identifier.issue3en_US
dc.identifier.pmid30730845en_US
dc.identifier.scopus2-s2.0-85061501915en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage304en_US
dc.identifier.urihttps://doi.org/10.1515/jpm-2018-0297
dc.identifier.urihttps://hdl.handle.net/11616/98654
dc.identifier.volume47en_US
dc.identifier.wosWOS:000462977300006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Perinatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectADAMTSen_US
dc.subjectinterleukin-6en_US
dc.subjectpreterm laboren_US
dc.subjecttumor necrosis factor-alphaen_US
dc.titleAssociations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnanciesen_US
dc.typeArticleen_US

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