The relationship between rheumatoid arthritis and epicardial fat thickness, and serum levels of chemerin, adropin, and betatrophin

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dc.contributor.authorEkinci, Bilge
dc.contributor.authorMertoglu, Cuma
dc.contributor.authorCoskun, Resit
dc.contributor.authorArslan, Yusuf Kemal
dc.contributor.authorCoban, Taha Abdulkadir
dc.contributor.authorOzcicek, Fatih
dc.date.accessioned2026-04-04T13:32:58Z
dc.date.available2026-04-04T13:32:58Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground. Cardiovascular diseases (CVDs) are highly prevalent among patients with rheumatoid arthritis (RA). Epicardial adipose tissue, serum betatrophin, chemerin, and adropin levels are factors associated with atherosclerosis and cardiovascular involvement. Objectives. This study aimed to investigate the relationship between RA and epicardial fat thickness (EFT), as well as serum betatrophin, chemerin and adropin levels. Materials and methods. This cross-sectional study included 80 patients (62 women and 18 men) diagnosed with RA according to the American College of Rheumatology/The European Alliance of Associations for Rheumatology (ACR/EULAR) 2010 RA classification criteria and 80 healthy controls (64 women and 16 men). Exclusion criteria comprised other autoimmune diseases, CVDs, diabetes mellitus, other endocrine disorders, acute or chronic pancreatic disorders, malignancy, pregnancy, breastfeeding, or antihyperlipidemic drug usage. Serum betatrophin, chemerin and adropin concentrations were measured. Epicardial fat thickness was evaluated with transthoracic echocardiography. Results. Adropin levels were significantly lower in the RA group compared to the control group (p < 0.001). Chemerin levels and EFT were significantly higher in the RA group than in the control group (p = 0.016, p < 0.001, respectively). When assessing the relationship between biomarkers and EFT in RA patients, a strong positive correlation was observed between chemerin and EFT (r = 0.73, p = 0.046) in patients with high disease activity. Conclusions. Epicardial fat thickness, as an indicator of cardiovascular involvement, is higher in patients with RA. Moreover, high chemerin levels and low adropin levels in these patients may be indicative of cardiovascular involvement.
dc.description.sponsorshipResearch Fund of Erzincan Binali Yildirim University [TSA-2020-680]
dc.description.sponsorshipFunding This study was supported by Research Fund of Erzincan Binali Yildirim University; scientific project No. TSA-2020-680.
dc.identifier.doi10.17219/acem/190059
dc.identifier.endpage715
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue5
dc.identifier.orcid0000-0003-1308-8569
dc.identifier.orcid0000-0002-0312-2009
dc.identifier.pmid39302228
dc.identifier.scopus2-s2.0-105007050981
dc.identifier.scopusqualityQ1
dc.identifier.startpage709
dc.identifier.urihttps://doi.org/10.17219/acem/190059
dc.identifier.urihttps://hdl.handle.net/11616/108839
dc.identifier.volume34
dc.identifier.wosWOS:001318485300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWroclaw Medical Univ
dc.relation.ispartofAdvances in Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectrheumatoid arthritis
dc.subjectchemerin
dc.subjectepicardial fat thickness
dc.subjectbetatrophin
dc.subjectadropin
dc.titleThe relationship between rheumatoid arthritis and epicardial fat thickness, and serum levels of chemerin, adropin, and betatrophin
dc.typeArticle

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