Investigation of ICAM 1 and 3 integrin gene variations in patients with brain tumors

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dc.authoridTR109090en_US
dc.authoridTR48369en_US
dc.authoridTR167477en_US
dc.authoridTR206344en_US
dc.authoridTR223147en_US
dc.authoridTR12545en_US
dc.contributor.authorYılmaz, Ümit
dc.contributor.authorZeybek, Şakir Ümit
dc.contributor.authorTimirci Kahraman,Özlem
dc.contributor.authorKafadar, Ali Metin
dc.contributor.authorToptaş, Bahar
dc.contributor.authorYılmaz, Nesibe
dc.contributor.authorÇelik, Faruk
dc.contributor.authorYaylım, İlhan
dc.date.accessioned2017-04-14T06:41:32Z
dc.date.available2017-04-14T06:41:32Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Primary brain tumors constitute a small percent of all malignant cancers, but their etiology remains poorly understood. β3 integrin (ITGB3) has been recognized to play influential roles in angiogenesis, tumor growth and metastasis. Intercellular adhesion molecule-1 (ICAM-1) is a surface glycoprotein important for tumor invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and ITGB3 could be associated with brain cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between brain tumor risk and ICAM-1 and β3 integrin gene polymorphisms. Materials and Methods: The study covered 92 patients with primary brain tumors and 92 age-matched healthy control subjects. Evaluation of β3 integrin (Leu33Pro (rs5918)) and ICAM-1 (R241G (rs1799969) and K469E (rs5498)) gene polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: According to results of our research, the A allele of the ICAM-1 R241G gene polymorphism appeared to be a risk factor for primary brain tumors (p<0.001). Similarly, the frequency of the A mutant allele of ICAM-1 R241G was statistically significant in patients with brain tumors classified as glioma (p<0.001). When allele and genotype distributions of ICAM- 1 K469E, ICAM-1 R241G and β3 integrin Leu33Pro gene polymorphisms were evaluated with age, sex, and smoking, there were no statistically significant differences. Haplotype analysis revealed that the frequencies of GAC (rs1799969-rs5498-rs5918) and GAT (rs1799969-rs5498-rs5918) haplotypes were significantly lower in patients as compared with controls (p=0.001; p=0.036 respectively). Conclusions: This study provides the first evidence that ICAM-1 R241G SNP significantly contributes to the risk of primary brain tumors in a Turkish population. In addition, our results suggest that ICAM-1 R241G in combination ICAM-1 K469E may have protective effects against the development of brain cancer.en_US
dc.identifier.citationYılmaz, Ü. Zeybek, Ş. Ü. Timirci Kahraman,Ö. Kafadar, A.M. Toptaş, B. Yılmaz, N. Çelik, F. Yaylım, İ. (2013). Investigation of ICAM 1 and 3 Integrin Gene Variations in Patients with Brain Tumors. Asian Pacific Journal of Cancer Prevention, 14(10), 5929–5934.en_US
dc.identifier.doi10.7314/APJCP.2013.14.10.5929en_US
dc.identifier.endpage5934en_US
dc.identifier.issn1513-7368
dc.identifier.issue10en_US
dc.identifier.startpage5929en_US
dc.identifier.urihttp://koreascience.or.kr/journal/view.jsp?kj=POCPA9&py=2013&vnc=v14n10&sp=5929
dc.identifier.urihttps://hdl.handle.net/11616/6664
dc.identifier.volume14en_US
dc.language.isoenen_US
dc.publisherAsian Pacific Journal of Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCanceren_US
dc.subjectBrain tumoren_US
dc.subjectPolymorphismen_US
dc.subjectICAM-1en_US
dc.subjectβ3en_US
dc.subjectintegrinen_US
dc.titleInvestigation of ICAM 1 and 3 integrin gene variations in patients with brain tumorsen_US
dc.typeArticleen_US

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