Effects of meteorin-like hormone on endocrine function of hypothalamo-hypophysial system and peripheral uncoupling proteins in rats

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dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridSEKERCI, Guldeniz/0000-0002-0811-4454
dc.authorwosidŞekerci, Güldeniz/IVH-2033-2023
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.contributor.authorSekerci, Guldeniz
dc.contributor.authorErden, Yavuz
dc.contributor.authorTekin, Suat
dc.date.accessioned2024-08-04T20:51:47Z
dc.date.available2024-08-04T20:51:47Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Meteorin-like hormone (Metrnl) is a peptide secreted from the adipose tissue and modulates the whole-body energy metabolism. Metrnl release into the circulation is influenced by obesity, cold exposure, and exercise. Thyroid hormones also exert many of their effects on metabolism through uncoupling proteins (UCPs). This study aimed to determine effect of Metrnl on hypothalamo-hypophysier-thyroid axis and energy metabolism and reveal the possible involvement of UCPs in this process. Methods and results Fourty male Sprague-Dawley rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 nM Metrnl. Hypothalamus, muscle, white adipose tissue (WAT) and brown adipose tissue (BAT) samples were collected to detect thyrotropin-releasing hormone (TRH), and UCP1 and UCP3 protein levels by western blot analysis. Serum thyroid-stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4) hormone levels were determined by enzyme-linked immunosorbent assay. Central infusion of Metrnl caused significant increase in serum TSH, T3 and T4 levels compared to control (p < 0.05). After Metrnl treatment, there were significant increases in TRH in hypothalamus tissue, UCP1 in WAT and BAT; and UCP3 protein in the muscle tissue (p < 0.05). Conclusions The findings that Metrnl induced increases in the peripheral UCPs and hypothalamus-pituitary-thyroid axis hormones implicate a role for this hormone in body energy homeostasis through UCP-mediated mechanisms.en_US
dc.description.sponsorshipScientific Research Projects unit of Inonu University [TYL-2020-2219]en_US
dc.description.sponsorshipThis study was supported by Scientific Research Projects unit of Inonu University (Project Number: TYL-2020-2219).en_US
dc.identifier.doi10.1007/s11033-022-07374-5
dc.identifier.endpage5925en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue7en_US
dc.identifier.pmid35332411en_US
dc.identifier.scopus2-s2.0-85127090956en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage5919en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-022-07374-5
dc.identifier.urihttps://hdl.handle.net/11616/100560
dc.identifier.volume49en_US
dc.identifier.wosWOS:000780288300002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMetrnlen_US
dc.subjectThyroid hormonesen_US
dc.subjectEnergy useen_US
dc.subjectUCP1en_US
dc.subjectUCP3en_US
dc.titleEffects of meteorin-like hormone on endocrine function of hypothalamo-hypophysial system and peripheral uncoupling proteins in ratsen_US
dc.typeArticleen_US

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