The therapeutic efficacy of dexpanthenol on sciatic nerve injury in a rat model

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridkorkmaz, mehmet/0000-0001-7498-6763
dc.authoridErdem, Mehmet Nuri/0000-0001-7377-6393
dc.authorwosidceylan, mehmet fethi/ABF-1126-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidkorkmaz, mehmet/W-1966-2017
dc.authorwosidErdem, Mehmet Nuri/J-9767-2018
dc.contributor.authorKorkmaz, Mehmet Fatih
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorErdem, Mehmet Nuri
dc.contributor.authorCeylan, Mehmet Fethi
dc.contributor.authorEdiz, Levent
dc.contributor.authorSamdanci, Emine
dc.contributor.authorKekilli, Ersoy
dc.date.accessioned2024-08-04T20:47:15Z
dc.date.available2024-08-04T20:47:15Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate histopathological, functional and bone densitometry examinations of the beneficial effects of dexpanthenol (DEX) on nerve regeneration in a rat model of peripheral nerve crush injury. Methods: Thirty adult Sprague-Dawley rats were divided equally into three groups. A crush injury was simulated in all rats by clamping the right sciatic nerve for one minute. In group 1, one day before the surgical procedure, 500 mg/kg DEX administered via intraperitoneally (ip) was initiated and continued three times in a week during the experiment period as 28 days. In group 2, rats received a dose of 10 mg/kg DEX to investigate possible effects of DEX alone. Group 3 served as the control (sciatic nerve injury) and was not given any drugs. Results: Performance was significantly lower in group 3 compared to the drug treatment groups during the rotarod test (30 rpm and 40 rpm) (p < 0.05). After a while, the rats which were able to remain on the rod was significantly lower in group 3 during the acceleration test (p < 0.05). Hot plate latency test results in group 3 were significantly lower when compared to the other groups (p < 0.05). Conclusion: DEX appears to be useful as a supportive clinical agent for the treatment of pain and nerve damage.en_US
dc.identifier.doi10.1080/02688697.2020.1749984
dc.identifier.endpage401en_US
dc.identifier.issn0268-8697
dc.identifier.issn1360-046X
dc.identifier.issue4en_US
dc.identifier.pmid32297525en_US
dc.identifier.scopus2-s2.0-85083672906en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage397en_US
dc.identifier.urihttps://doi.org/10.1080/02688697.2020.1749984
dc.identifier.urihttps://hdl.handle.net/11616/99256
dc.identifier.volume34en_US
dc.identifier.wosWOS:000527707200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBritish Journal of Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone mineral densityen_US
dc.subjectdexpanthenolen_US
dc.subjectperipheral nerve traumaen_US
dc.subjectstatic sciatic indexen_US
dc.titleThe therapeutic efficacy of dexpanthenol on sciatic nerve injury in a rat modelen_US
dc.typeArticleen_US

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