Corneal endothelial changes in long-term cannabinoid users

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dc.authoridPolat, Nihat/0000-0002-1735-1363
dc.authoridTuncer Firat, Ilknur/0000-0003-1491-8659
dc.authorwosidPolat, Nihat/ABI-7316-2020
dc.contributor.authorPolat, Nihat
dc.contributor.authorCumurcu, Birgul
dc.contributor.authorCumurcu, Tongabay
dc.contributor.authorTuncer, Ilknur
dc.date.accessioned2024-08-04T20:43:10Z
dc.date.available2024-08-04T20:43:10Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was at evaluating the effects of long-term cannabis use on the corneal endothelial cells with the specular microscopy.Methods: The study enrolled 28 eyes of 28 patients diagnosed with cannabinoid use disorder. The cannabinoid group was selected among patients who had been using the substance for three days or more per week over the past one year. Thirty-two eyes of 32 age- and sex-matched healthy individuals enrolled as control group in the study. Corneal endothelial cell density (CD), coefficient of variation (CV) and hexagonal cell ratio (HEX) values were analyzed by specular microscopy.Results: The mean CD was 2900211 cells/mm(2) in the cannabinoid group and 3097 +/- 214 cells/mm(2) in the control group (p<0.01). There was a significant decrease in cannabinoid group. The mean CV was 29 +/- 7 and 27 +/- 4 in the cannabinoid and control groups, respectively (p>0.05). No significant difference was present between the cannabinoid and the control groups in terms of mean CV value. The mean HEX was 52 +/- 5% in the cannabinoid group and 53 +/- 10% in the control group (p>0.05). There was not a significant difference between the cannabinoid and the control groups in terms of mean HEX value.Conclusion: A significant decrease in CD was found in cannabinoid users compared the control group.en_US
dc.identifier.doi10.1080/15569527.2017.1322098
dc.identifier.endpage23en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue1en_US
dc.identifier.pmid28427301en_US
dc.identifier.scopus2-s2.0-85019149948en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://doi.org/10.1080/15569527.2017.1322098
dc.identifier.urihttps://hdl.handle.net/11616/97814
dc.identifier.volume37en_US
dc.identifier.wosWOS:000427835700004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous and Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCannabinoidsen_US
dc.subjectcorneaen_US
dc.subjectendothelial cellsen_US
dc.subjectspecular microscopyen_US
dc.subjecttoxicityen_US
dc.titleCorneal endothelial changes in long-term cannabinoid usersen_US
dc.typeArticleen_US

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