The protective effect of melatonin on ischemia-reperfusion injury in the groin (inferior epigastric) flap model in rats

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorGurlek, A
dc.contributor.authorCelik, M
dc.contributor.authorParlakpinar, H
dc.contributor.authorAydogan, H
dc.contributor.authorBay-Karabulut, A
dc.date.accessioned2024-08-04T20:15:22Z
dc.date.available2024-08-04T20:15:22Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractInadequate blood perfusion and ischemia-reperfusion (I/R) injury in the surgical skin flap are believed to be the major factors that cause harmful changes within the tissue and vasculature, resulting in flap necrosis. Reactive oxygen radical species (ROS), in part, are believed to play an important role in this injury. Melatonin, in many physiological conditions, has been shown to have direct and indirect antioxidative effects and free-radical-scavenging properties. Therefore, it may have a beneficial effect on I/R-induced flap injury. In this study, the possible protective effects of melatonin were investigated in I/R injury of rat epigastric (axial pattern) flaps. Ischemia was achieved for 12 h by occlusion of inferior epigastric artery. Melatonin or vehicle was administered 1 h before flap elevation and was continued for 6 days after ischemia. I/R injury elevated malondialdehyde (MDA), an end product of lipid peroxidation, and nitric oxide (NO) levels while the glutathione (GSH) content was reduced. Myeloperoxidase (MPO) activity, which is known to be related to tissue neutrophil accumulation, was found to be statistically higher in the I/R group when compared with the sham group. Administration of melatonin significantly decreased MDA, NO and MPO levels and elevated the GSH content. Moreover, melatonin reduced the flap necrosis area, which was determined using a planimetric method. In conclusion, melatonin, a potent scavenger of free radicals, plays a major role in preventing the inferior epigastric arterial I/R-induced flap necrosis, based on planimetric flap survival and biochemical results. The beneficial effects of melatonin in I/R injury implies the involvement of free radicals in flap damage.en_US
dc.identifier.doi10.1111/j.1600-079X.2006.00319.x
dc.identifier.endpage317en_US
dc.identifier.issn0742-3098
dc.identifier.issue4en_US
dc.identifier.pmid16635018en_US
dc.identifier.scopus2-s2.0-33645458310en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage312en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-079X.2006.00319.x
dc.identifier.urihttps://hdl.handle.net/11616/94339
dc.identifier.volume40en_US
dc.identifier.wosWOS:000236460000004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectflapen_US
dc.subjectmelatoninen_US
dc.subjectmyeloperoxidase activityen_US
dc.subjectreactive oxygen radicalsen_US
dc.subjectraten_US
dc.titleThe protective effect of melatonin on ischemia-reperfusion injury in the groin (inferior epigastric) flap model in ratsen_US
dc.typeArticleen_US

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