Assessment of the biocompatibility of mineral trioxide aggregate, bioaggregate, and biodentine in the subcutaneous tissue of rats

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dc.authoridBulut, Elcin Tekin/0000-0001-8382-9065
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridsimsek, neslihan/0000-0003-1142-9016
dc.authoridKeleş, Ali/0000-0003-2835-767X
dc.authorwosidalan, hilal/ABH-9301-2020
dc.authorwosidBulut, Elcin Tekin/O-9884-2015
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidsimsek, neslihan/ABF-1071-2020
dc.authorwosidKeleş, Ali/J-5897-2015
dc.contributor.authorSimsek, N.
dc.contributor.authorAlan, H.
dc.contributor.authorAhmetoglu, F.
dc.contributor.authorTaslidere, E.
dc.contributor.authorBulut, E. T.
dc.contributor.authorKeles, A.
dc.date.accessioned2024-08-04T20:41:10Z
dc.date.available2024-08-04T20:41:10Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The objective of this study was to evaluate the tissue inflammation caused by three endodontic repair materials. Materials and Methods: The materials included micro mega-mineral trioxide aggregate (MM-MTA), bioaggregate (BA), and biodentine (BD), which were implanted into the subcutaneous tissue of rats. The tissue samples for histological examination were prepared. The infiltration of lymphocytes and macrophages into the tissue was examined to assess the inflammatory response. Results: Lymphocyte infiltration: A significant increase was detected in the MM-MTA and BA groups on the 7th and 14th days as compared with the control (7th day P = 0.0001, 14th day P = 0.0176). There was no difference between the groups on the 45th day (P = 0.1730). Lymphocyte infiltration had decreased over time in all groups. Macrophage infiltration: There was a significant increase by the 7th day in the test groups as compared to the control group (P = 0.007). However, there was no difference between the experimental groups on the 14th (P = 0.2708) and 45th (P = 0.1291) days. Conclusion: While MM-MTA and BA showed a similar biocompatibility, BD was more biocompatible than MM-MTA and BA in the 1st week of the experiment. However, there was no difference between the materials at the end of the 45th day. MM-MTA, BA, and BD can be considered suitable endodontic repair materials.en_US
dc.description.sponsorshipInonu University/Turkey, Scientific Research Projects Unit [2013/117]en_US
dc.description.sponsorshipThis project was supported by Inonu University/Turkey, Scientific Research Projects Unit (2013/117).en_US
dc.identifier.doi10.4103/1119-3077.154219
dc.identifier.endpage743en_US
dc.identifier.issn1119-3077
dc.identifier.issue6en_US
dc.identifier.pmid26289510en_US
dc.identifier.scopus2-s2.0-84940561143en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage739en_US
dc.identifier.urihttps://doi.org/10.4103/1119-3077.154219
dc.identifier.urihttps://hdl.handle.net/11616/96962
dc.identifier.volume18en_US
dc.identifier.wosWOS:000376164400006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioaggregateen_US
dc.subjectbiocompatible materialsen_US
dc.subjectbiodentineen_US
dc.subjectendodonticsen_US
dc.titleAssessment of the biocompatibility of mineral trioxide aggregate, bioaggregate, and biodentine in the subcutaneous tissue of ratsen_US
dc.typeArticleen_US

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