Preparation, characterization, and in vitro release study of vincristine sulfate-loaded chitosan-polyethylene glycol-oleic acid composites

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridUlu, Ahmet/0000-0002-4447-6233
dc.authoridKoytepe, Suleyman/0000-0002-4788-278X
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidUlu, Ahmet/L-5180-2016
dc.contributor.authorBakmaz, Dilara
dc.contributor.authorUlu, Ahmet
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:49:20Z
dc.date.available2024-08-04T20:49:20Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractVincristine sulfate (VCS) was used in combination with other chemotherapeutic agents for the treatment of a variety of cancers, including acute lymphoblastic leukemia, cervical cancer, and breast cancer. However, rapid release of the drug at the site of specific action was still a challenge for antitumor treatment. Recently, hybrid carriers bearing the versatile properties of each component were promising materials in order to improve the effects of therapeutic drugs. This work aimed to prepare and characterize chitosan (CHS)-polyethylene glycol (PEG)-oleic acid (OA) composites as a carrier for VCS delivery. The structure, thermal stability, and surface morphology of CHS/PEG/OA composites were characterized by using Fourier transform infrared spectroscopy, thermal gravimetric analysis, differential thermal analysis, differential scanning calorimeter, scanning electron microscopy, and atomic force microscopy. Additionally, swelling degree, water uptake capacity, gas permeability, water contact angle, and in vitro hydrolytic degradation properties of the composites were examined in detail. The VCS-loaded CHS/PEG/OA composites were prepared and drug-loading efficiency was evaluated. CPO-2 sample with a loading efficiency of 64.1 +/- 0.6% was selected for in vitro release(.) due to the highest drug loading efficiency. In vitro release behavior was performed in phosphate-buffered saline buffer (pH 7.4). The release of VCS was completed in almost 24 h and the release data were best fitted to Korsmeyer-Peppas model. The release results revealed that CHS/PEG/OA composites with slow-release behavior could be a promising drug carrier for therapeutic drugs such as VCS.en_US
dc.description.sponsorshipTUBITAK-BIDEB (Scientific and Technical Research Council of TurkeyDepartment of Science Fellowships and Grant Programmes (BIDEB)) [2209-A]en_US
dc.description.sponsorshipThis study was supported by the TUBITAK-BIDEB (Scientific and Technical Research Council of TurkeyDepartment of Science Fellowships and Grant Programmes (BIDEB) under grant no.2209-A.en_US
dc.identifier.doi10.1080/1023666X.2021.1887624
dc.identifier.endpage308en_US
dc.identifier.issn1023-666X
dc.identifier.issn1563-5341
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85101751250en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage291en_US
dc.identifier.urihttps://doi.org/10.1080/1023666X.2021.1887624
dc.identifier.urihttps://hdl.handle.net/11616/99791
dc.identifier.volume26en_US
dc.identifier.wosWOS:000621314300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Polymer Analysis and Characterizationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVincristine sulfateen_US
dc.subjectchemotherapeutic agentsen_US
dc.subjectchitosan– PEG– oleic aciden_US
dc.subjecthydrogelen_US
dc.subjectdrug deliveryen_US
dc.titlePreparation, characterization, and in vitro release study of vincristine sulfate-loaded chitosan-polyethylene glycol-oleic acid compositesen_US
dc.typeArticleen_US

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