The usefulness of GST lsoenzymes as markers of malignancy in urinary cytology

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dc.authorscopusid26644418800
dc.authorscopusid57213251975
dc.authorscopusid54402600100
dc.authorscopusid58294926500
dc.contributor.authorSerpil O.
dc.contributor.authorMurat K.
dc.contributor.authorEbru C.
dc.contributor.authorZiya A.
dc.date.accessioned2024-08-04T20:03:30Z
dc.date.available2024-08-04T20:03:30Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study investigated the usefulness of GST lsoenzymes immunostaining as an early marker of malignancy in urinary cytology. They are also correlated with cytopathology diagnosis. In this study, the slides from 22 patients of benign urinary cytology who have benign urinary diseases and 6 patients who have clinical diagnosis of bladder carcinoma were observed. The cytomorphological characteristics and the immunocytochemical expression of GST alpha (GSTA), pi (GSTP), mu (GSTM4), theta (GSTT 1) isoen2ymes were examined. Immunohistochemical examinations showed that the urothelial cancer cells had stronger staining intensity than the benign cells in 5 (83%) cases for GSTA, 5 (%83) cases for GSTP, 1(%17) case for GSTM4 and 4 (%67) cases for GSTT1. The atypical cells had stronger staining intensity than the benign cells in 10 (%45) cases for GSTA, 16 (%73) cases for GSTP, 12 (%55) cases for GSTM4 and 13(%59) cases for GSTT1. There was no significant difference in GSTA, GSTM4, GSTT1, GSTP expressions for benign, atypical and malign cells (p>0.05). In conclusion, GST lsoenzymes were not found to be markers of malignancy in urinary cytology. © IDOSI Publications, 2010.en_US
dc.identifier.endpage33en_US
dc.identifier.issn1995-8943
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-80155194153en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://hdl.handle.net/11616/91862
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofAcademic Journal of Cancer Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladder canceren_US
dc.subjectCytologen_US
dc.subjectGluthathione-S-transferaseen_US
dc.subjectImmunocytochemistryen_US
dc.subjectUrinaryen_US
dc.titleThe usefulness of GST lsoenzymes as markers of malignancy in urinary cytologyen_US
dc.typeArticleen_US

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