Diffusion-weighted imaging of the liver in assessing chronic liver disease: effects of fat and iron deposition on ADC values

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dc.authoridKahraman, Bayram/0000-0002-5447-1110
dc.authoridKahraman, Aysegul Sagir/0000-0002-2147-1181
dc.authoridKaraca, Leyla/0000-0001-9150-3823
dc.authoridMARAŞ ÖZDEMİR, ZEYNEP/0000-0003-1085-8978
dc.authorwosidKahraman, Bayram/HKM-4798-2023
dc.authorwosidKahraman, Aysegul Sagir/S-1526-2016
dc.authorwosidKaraca, Leyla/AAG-4002-2020
dc.authorwosidMARAŞ ÖZDEMİR, ZEYNEP/ABI-3319-2020
dc.contributor.authorKahraman, A. S.
dc.contributor.authorKahraman, B.
dc.contributor.authorOzdemir, Z. M.
dc.contributor.authorKaraca, L.
dc.contributor.authorSahin, N.
dc.contributor.authorYilmaz, S.
dc.date.accessioned2024-08-04T20:53:03Z
dc.date.available2024-08-04T20:53:03Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: This study was de-signed to evaluate whether fat and iron affect the apparent diffusion coefficient (ADC) values of the liver parenchyma in the settings of fibro-sis and inflammation.PATIENTS AND METHODS: We evaluated the diffusion-weighted images (DWIs) of 58 pa-tients with chronic liver disease and 48 con-trol subjects. Liver specimens of patients were assessed for fibrosis, necroinflammation, iron, and steatosis. Liver ADCs, spleen ADCs, and normalized liver ADCs (defined as the ratio of the liver ADC to spleen ADC) values were an-alyzed after stratifying patients with either fi-brosis stages or histology activity index (HAI) scores. The relationship between ADC values and histopathological findings was studied us-ing multiple linear regression analysis.RESULTS: The median liver and normalized liver ADC values were significantly lower in higher stages of fibrosis and HAI scores. Com-pared to the control group, patients with the highest stages of fibrosis and inflammation had significantly higher spleen ADCs. The ef-fect of the fibrosis stage on liver ADC and nor-malized liver ADC values was significant in the setting of inflammation, whereas the degree of steatosis and iron grade did not affect these ADC values.CONCLUSIONS: ADC values can distinguish both later stages of liver fibrosis and inflam-mation. There is no significant effect of fat and iron on ADC values. Therefore, DWI may be re-liable in evaluating liver fibrosis and inflamma-tion.en_US
dc.identifier.endpage6631en_US
dc.identifier.issn1128-3602
dc.identifier.issue18en_US
dc.identifier.pmid36196712en_US
dc.identifier.scopus2-s2.0-85139572408en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage6620en_US
dc.identifier.urihttps://hdl.handle.net/11616/100934
dc.identifier.volume26en_US
dc.identifier.wosWOS:000868310400024en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectADC measurementsen_US
dc.subjectChronic liver diseaseen_US
dc.subjectDiffusion-weighted MRIen_US
dc.subjectFaten_US
dc.subjectIronen_US
dc.subjectMagnetic resonance im-agingen_US
dc.titleDiffusion-weighted imaging of the liver in assessing chronic liver disease: effects of fat and iron deposition on ADC valuesen_US
dc.typeArticleen_US

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