Protective effect of resveratrol against renal oxidative stress in cholestasis

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorAra, C
dc.contributor.authorKarabulut, AB
dc.contributor.authorKirimlioglu, H
dc.contributor.authorCoban, S
dc.contributor.authorUgras, M
dc.contributor.authorKirimliglu, V
dc.contributor.authorYilmaz, S
dc.date.accessioned2024-08-04T20:14:52Z
dc.date.available2024-08-04T20:14:52Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/aims. This experimental study was designed to evaluate histological changes of the kidney and renal tissue levels of malondialdehyde (MDA), reduced glutathione (GSH), and nitric oxide (NO) and the effect of resveratrol on these metabolites after bile duct ligation in rats. Methods. Secondary biliary cirrhosis was induced by bile duct ligation for 28 days. Swiss albino rats were divided into three groups. Group 1: Sham (n=7), Group 2: Bile duct ligation (n=7), Group 3: Bile duct ligation plus resveratrol (n=7). Bile duct ligation (BDL) plus resveratrol group received 10 mgr/kg dose of resveratrol intraperitoneally daily throughout 28 days. Kidney tissues were harvested to determine the tissue levels of MDA, GSH, and NO activity. Liver and kidney tissues were removed for light microscopic evaluation. Results. Cholestasis was determined by biochemical and pathologic examination. In the resveratrol-treated rats, levels of MDA were significantly lower than those of the BDL group (p<0.04). The levels of GSH in the resveratrol-treated rats were significantly higher than those in the BDL group (p<0.01). The levels of NO in the resveratrol group were significantly lower than those in the BDL group (p<0.01). Conclusion. The present study demonstrates that intraperitoneal administration of resveratrol in bile duct ligated rats maintains antioxidant defenses and reduces kidney oxidative damage. This effect of resveratrol may be useful in the preservation of renal oxidative stress in cholestasis.en_US
dc.identifier.doi10.1081/JDI-200065221
dc.identifier.endpage440en_US
dc.identifier.issn0886-022X
dc.identifier.issue4en_US
dc.identifier.pmid16060133en_US
dc.identifier.scopus2-s2.0-22244462439en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage435en_US
dc.identifier.urihttps://doi.org/10.1081/JDI-200065221
dc.identifier.urihttps://hdl.handle.net/11616/94008
dc.identifier.volume27en_US
dc.identifier.wosWOS:000230582800015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbile duct ligationen_US
dc.subjectrenal oxidative stressen_US
dc.subjectresveratrolen_US
dc.titleProtective effect of resveratrol against renal oxidative stress in cholestasisen_US
dc.typeArticleen_US

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