The Histopathological Effect of Resveratrol in Thyroid Tissue of Rats Exposed to Cigarette Smoke

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dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authorwosidOzturk, Feral/A-2678-2016
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.contributor.authorKurus, Meltem
dc.contributor.authorSogutlu, Gokhan
dc.contributor.authorFirat, Yezdan
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorYologlu, Saim
dc.contributor.authorOzturk, Feral
dc.contributor.authorOtlu, Ali
dc.date.accessioned2024-08-04T20:32:14Z
dc.date.available2024-08-04T20:32:14Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to assess the histopathological effect of resveratrol in thyroid tissue of rats exposed to cigarette smoke. Material and Methods: Forty adult, male Wistar Albino rats were divided into four groups for an experiment of 6 weeks duration. Group I was the control group. Rats in group 2 were exposed to cigarette smoke only and rats in group 3 received daily intraperitoneal injections of resveratrol (10 mg/kg/d). Animals in group 4 were exposed to both cigarette smoke and intraperitoneal injections of resveratrol. Rats of all groups were sacrificed; their thyroid glands were removed and were examined histopathologically. Results: While the control group and the resveratrol group had normal thyroid tissue, in the group exposed to cigarette smoke there was a significant decrease in follicles and differentiation of epithelial cells from cubic to flat cells. There was intracytoplasmic vacuolization in some epithelial cells, irregularity in follicular cells decreasing area and cell infiltrations. On the other hand, we observed significant improvement in these histopathological differences in the group that was exposed to both cigarette smoke and resveratrol. Conclusion: Resveratrol has healing effects on the damage of thyroid tissue of rats that are exposed to cigarette smoke at a dose and duration tested in this study.en_US
dc.identifier.endpage1190en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-73449087372en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1183en_US
dc.identifier.urihttps://hdl.handle.net/11616/94939
dc.identifier.volume29en_US
dc.identifier.wosWOS:000272651300020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSmokingen_US
dc.subjectthyroid glanden_US
dc.subjectresveratrolen_US
dc.subjectpathologyen_US
dc.titleThe Histopathological Effect of Resveratrol in Thyroid Tissue of Rats Exposed to Cigarette Smokeen_US
dc.typeArticleen_US

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