Protective effects of quercetin against testis damage caused by cisplatin

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dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridBOSTANCIERI, NURAY/0000-0002-3765-8274
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidElbe, Hulya/D-5261-2015
dc.contributor.authorBostancieri, Nuray
dc.contributor.authorTaslidere, Asli
dc.contributor.authorElbe, Hulya
dc.contributor.authorTaslidere, Elif
dc.date.accessioned2024-08-04T20:50:15Z
dc.date.available2024-08-04T20:50:15Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated the effects of quercetin on cisplatin induced testicular toxicity using histopathological, immunohistochemical and biochemical methods. We used four groups of Wistar albino male: control, quercetin, cisplatin, cisplatin + quercetin. We measured tissue malondialdehyde (MDA) and catalase (CAT) biochemically. We assessed apoptosis as indicated by P63 immunoreactivity. Testis tissues of the control group exhibited normal histology. In the cisplatin group, the diameter of the seminiferous tubule and thickness of the germinal epithelium were decreased compared to the control group. In the cisplatin group, degeneration of the germinal epithelium, cell separation from the basal membrane, giant cell formation, cell loss, atrophy and vacuolization were observed in the seminiferous tubule. We found hyalinization around the seminiferous tubule, intertubule hyalinization and perivascular fibrosis. In the cisplatin + quercetin group, we found that quercetin decreased atrophy, giant cell formation and vacuolization significantly. We found that quercetin exhibited ameliorative effects following cisplatin induced testicular damage.en_US
dc.identifier.doi10.1080/10520295.2021.1924405
dc.identifier.endpage184en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.pmid34030543en_US
dc.identifier.scopus2-s2.0-85106416083en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage180en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1924405
dc.identifier.urihttps://hdl.handle.net/11616/99950
dc.identifier.volume97en_US
dc.identifier.wosWOS:000654259600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectcisplatinen_US
dc.subjectp63en_US
dc.subjectquercetinen_US
dc.subjectratsen_US
dc.subjecttestisen_US
dc.titleProtective effects of quercetin against testis damage caused by cisplatinen_US
dc.typeArticleen_US

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