Effect of leflunomide on liver regeneration after partial hepatectomy in rats

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dc.authoridKaradag Soylu, Nese/0000-0002-6303-5484
dc.authoridDemircan, Mehmet/0000-0002-4022-1276
dc.authorwosidKaradag Soylu, Nese/ABH-9544-2020
dc.authorwosidDemircan, Mehmet/AAW-7162-2020
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidDemircan, Mehmet/B-1904-2008
dc.contributor.authorKaraman, Abdurrahman
dc.contributor.authorKirimlioglu, Hale
dc.contributor.authorTas, Erkan
dc.contributor.authorKaradag, Nese
dc.contributor.authorGulsul, Cebrail
dc.contributor.authorFadillioglu, Ersin
dc.contributor.authorDemircan, Mehmet
dc.date.accessioned2024-08-04T20:32:19Z
dc.date.available2024-08-04T20:32:19Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPartial hepatectomy (PH) can be an inevitable surgical therapy in some conditions, such as hepatic malignancies, trauma or partial liver transplantation. Its capacity for regeneration distinguishes the liver from other essential organs. Regeneration is a complex process involving growth factors, cytokines, transcription factors, hormones, and oxidative stres products. In the event of ineffective or total absent liver regeneration, the lifethreatening picture of acute liver failure may supervene. In the present research, we studied the effect of leflunomide, a novel immunosuppressive and anti-inflammatory agent against autoimmune disease, on hepatic regeneration after PH in Wistar Albino rats. Thirty-five Wistar albino rats were divided into five groups: group 1, control; group 2, sham; group 3, drug control (was treated with leflunomide 10 mg/kg/d/i.g.); group 4, PH; group 5, PH + leflunomide. As for PH, approximately 70% of the rat liver was surgically removed under general anesthesia. On postoperative day 3, all rats were humanely killed. Catalase (CAT), superooxide dismutase (SOD) and myeloperoxidase (MPO) activities with malondialdehyde (MDA), nitric oxide and protein carbonyl (PC) levels were determined in remnant liver tissue. Inflammatory process and liver regeneration were evaluated with H&E and KI67, respectively. The tissue levels of MDA, PC and MPO were lower in group 5 than levels in group 1. PH significantly decreased the enzymatic activity of CAT (p < 0.05) and SOD. This reduction was significantly improved by the treatment with leflunomide. Histopathologically the enhancement of the liver parenchymal regeneration in the group 5 was significantly greater than the group 4. The findings imply that oxidative stress products play a preventive role in liver regeneration after PH and leflunomide ameliorates the regeneration probably by the radical scavenging and antioxidant activities.en_US
dc.identifier.doi10.1007/s00383-009-2529-1
dc.identifier.endpage226en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue2en_US
dc.identifier.pmid20128110en_US
dc.identifier.scopus2-s2.0-77649236478en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-009-2529-1
dc.identifier.urihttps://hdl.handle.net/11616/94993
dc.identifier.volume26en_US
dc.identifier.wosWOS:000273812600015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeflunomideen_US
dc.subjectPartial hepatectomyen_US
dc.subjectLiver regenerationen_US
dc.subjectOxidative stressen_US
dc.subjectLipid peroxidationen_US
dc.titleEffect of leflunomide on liver regeneration after partial hepatectomy in ratsen_US
dc.typeArticleen_US

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