The protective effects of Prunus armeniaca L (apricot) against methotrexate-induced oxidative damage and apoptosis in rat kidney

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dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorVardi, Nigar
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorAtes, Burhan
dc.contributor.authorCetin, Asli
dc.contributor.authorOtlu, Ali
dc.date.accessioned2024-08-04T20:38:01Z
dc.date.available2024-08-04T20:38:01Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was conducted to evaluate a possible protective role of apricot in apoptotic cell death induced by methotrexate (MTX) and renal damage by different histological and biochemical parameters. Twenty-eight rats were divided into four groups, control, apricot, methotrexate, and apricot + methotrexate. Methotrexate induced renal failure, as shown by significant serum creatinine and urea elevation. Additionally, the results indicated that methotrexate significantly induced lipid peroxidation and reduced antioxidant activities in rats. In contrast, apricot significantly prevented toxic effects of methotrexate via increased catalase, superoxide dismutase, and glutathione levels but decreased formation of malondialdehyde. Also, it was determined that exposure to methotrexate leads to significant histological damage in kidney tissue such as glomerulosclerosis and apoptosis. On the other hand, these effects can be eliminated with apricot diet. These data indicate that apricot may be useful in preventing undesirable effects of MTX such as nephrotoxicity.en_US
dc.description.sponsorshipScientific Research Fund of Inonu University [2005/78]; Apricot Research Foundation of Malatya Provinceen_US
dc.description.sponsorshipThis study was supported by a grant from the Scientific Research Fund of Inonu University (project number 2005/78) and the Apricot Research Foundation of Malatya Province. Total caloric composition of the standard diet and diet with dried apricot was assayed by Prof. Dr. Kazim Sahin, who was on duty in Animal Nutrition and Nutritional Diseases department at Firat University in Elazig/Turkey.en_US
dc.identifier.doi10.1007/s13105-012-0219-2
dc.identifier.endpage381en_US
dc.identifier.issn1138-7548
dc.identifier.issn1877-8755
dc.identifier.issue3en_US
dc.identifier.pmid23143813en_US
dc.identifier.scopus2-s2.0-84892828492en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage371en_US
dc.identifier.urihttps://doi.org/10.1007/s13105-012-0219-2
dc.identifier.urihttps://hdl.handle.net/11616/96329
dc.identifier.volume69en_US
dc.identifier.wosWOS:000322730300003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApricoten_US
dc.subjectKidneyen_US
dc.subjectApoptosisen_US
dc.subjectNutritional antioxidantsen_US
dc.subjectRaten_US
dc.titleThe protective effects of Prunus armeniaca L (apricot) against methotrexate-induced oxidative damage and apoptosis in rat kidneyen_US
dc.typeArticleen_US

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