N-Heterocyclic carbene-Pd(II)-PPh3 complexes as a new highly efficient catalyst system for the Sonogashira cross-coupling reaction: Synthesis, characterization and biological activities

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dc.authoridYaşar, Sedat/0000-0001-7285-2761
dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridHarrath, Abdel Halim/0000-0002-2170-1303;
dc.authorwosidYaşar, Sedat/ABG-8356-2020
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.authorwosidMansour, Lamjed/AAD-8613-2019
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidHarrath, Abdel Halim/K-2166-2014
dc.authorwosidMANSOUR, Lamjed/AAO-6201-2020
dc.contributor.authorBoubakri, L.
dc.contributor.authorMansour, L.
dc.contributor.authorHarrath, A. H.
dc.contributor.authorOzdemir, I.
dc.contributor.authorYasar, S.
dc.contributor.authorHamdi, N.
dc.date.accessioned2024-08-04T20:44:16Z
dc.date.available2024-08-04T20:44:16Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA novel series of N-heterocyclic carbene-phosphine palladium(II) complexes has been synthesized and fully characterized by IR, H-1 NMR, C-13 NMR, and P-31 NMR spectroscopies, and elemental analysis. The new N-heterocyclic carbene (NHC)-phosphine palladium(II) complexes 3a-h have been easily prepared by the reaction of the corresponding PEPPSI (pyridine-enhanced precatalyst preparation stabilization and initiation) complexes 2a-h and triphenylphosphine in dichloromethane in high yields. These complexes were applied as catalyst precursors which efficiently catalyzed Sonogashira reactions between aryl bromides and phenylacetylene to afford the corresponding products in good yields. The bulky NHC-Pd-PPh3 complexes 3 were tested against Gram-positive and Gram-negative bacteria to study their biological activity. All the complexes exhibit antibacterial against these organisms. Investigation of the antiacetylcholinesterase activity of the studied complexes showed that compounds 3a and 3b exhibited moderate activity at 100 mu g mL-1 and product 3b is the most active.en_US
dc.description.sponsorshipDeanship of Scientific Research at King Saud University [RG-1435-023]en_US
dc.description.sponsorshipThe authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for its funding this research group no. (RG-1435-023).en_US
dc.identifier.doi10.1080/00958972.2018.1430791
dc.identifier.endpage199en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85041597543en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://doi.org/10.1080/00958972.2018.1430791
dc.identifier.urihttps://hdl.handle.net/11616/98145
dc.identifier.volume71en_US
dc.identifier.wosWOS:000426924900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Coordination Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbineen_US
dc.subjectSonogashira reactionen_US
dc.subjectpalladium catalysten_US
dc.subjectbiological activitiesen_US
dc.titleN-Heterocyclic carbene-Pd(II)-PPh3 complexes as a new highly efficient catalyst system for the Sonogashira cross-coupling reaction: Synthesis, characterization and biological activitiesen_US
dc.typeArticleen_US

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