Synthesis, characterization and anticancer activity of allyl substituted N-Heterocyclic carbene silver(I) complexes

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dc.authoridTahir, Muhammad Nawaz/0000-0002-6815-9806
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridŞAHİN-BÖLÜKBAŞI, Serap/0000-0003-1057-2558
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authorwosidTahir, Muhammad Nawaz/HPB-5726-2023
dc.authorwosidŞAHİN, Neslihan/F-6402-2019
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidŞAHİN-BÖLÜKBAŞI, Serap/ABJ-7836-2022
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.contributor.authorSahin, Neslihan
dc.contributor.authorSahin-Bolukbasi, Serap
dc.contributor.authorTahir, Muhammad Nawaz
dc.contributor.authorArici, Cengiz
dc.contributor.authorCevik, Esranur
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:45:32Z
dc.date.available2024-08-04T20:45:32Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMetal N-heterocyclic carbene (NHC) complexes have attracted considerable attention in biological fields for their potential applications in cancer and antimicrobial therapies. In this study, four new benzimidazole-based N-heterocyclic carbene salts (la-d) and their silver (I) complexes (2a-d) were synthesized. All new compounds were characterized by elemental analysis, FT-IR, H-1 NMR and, C-13 NMR spectroscopy. Additionally, single crystal structural studies for complex 2d show that the benzene rings (C9-C14) and the central benzimidazole ring system make dihedral angles of 83.58(13)degrees. The Ag-Cl and Ag-C single bond lengths are 2.3267(8) and 2.087(3) angstrom, respectively. The C-Ag-Cl bond angle is 175.20(7)degrees. The prop-1-ene moiety attached at the second N-atom of benzimidazole is disordered at two set of sites with an occupancy ratio of 0.592(6): 0.408(6). There is one intramolecular hydrogen bond interaction between C22A-H22A... N2. The salts and Ag-complexes were further evaluated for their in vitro anticancer activities against DU-145 human prostate cancer cells, MCF-7, MDA-MB-231 human breast cancer cells and L-929 non-cancer cell for 24 h, 48 h and 72 h using the MTT assay. The Ag(I)-NHC complexes (2a-d) showed a dose and time-dependent cytotoxic activity against all cell lines. The IC(50)s for all Ag(I) NHC complexes lower than 1 mu M for 72 h time points on cancer cells. The results showed that complex 2d exhibited the highest activity against all cancer cell lines studied. Further, the complexes had relatively higher cytotoxicity to cancer cells than to non-cancer cell lines. (C) 2018 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK-BIDEB-2218]; National Research Fellowship Programmeen_US
dc.description.sponsorshipThe authors thank the Scientific and Technological Research Council of Turkey (TUBITAK-BIDEB-2218), the National Research Fellowship Programme for grants to N. S.en_US
dc.identifier.doi10.1016/j.molstruc.2018.10.094
dc.identifier.endpage99en_US
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85057145308en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2018.10.094
dc.identifier.urihttps://hdl.handle.net/11616/98545
dc.identifier.volume1179en_US
dc.identifier.wosWOS:000456491500010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbeneen_US
dc.subjectSilver complexen_US
dc.subjectBenzimidazole-2-ylideneen_US
dc.subjectAnticancer activityen_US
dc.titleSynthesis, characterization and anticancer activity of allyl substituted N-Heterocyclic carbene silver(I) complexesen_US
dc.typeArticleen_US

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