Effect of BQ-123 and nitric oxide inhibition on liver in rats after renal ischemia-reperefusion injury

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dc.authorscopusid7004878674
dc.authorscopusid7006831777
dc.authorscopusid6701336286
dc.contributor.authorEmre M.H.
dc.contributor.authorErdogan H.
dc.contributor.authorFadillioglu E.
dc.date.accessioned2024-08-04T19:59:21Z
dc.date.available2024-08-04T19:59:21Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIschemia-reperfusion (I/R) injury induces an inflammatory response and production of oxygen-derived reactive species which affect many organs including heart, brain, kidney and gastrointestinal tract. The aim of this study was to assess the hepatic changes after renal I/R injury. Male Sprague Dawley rats were subjected to either sham operation or treatment with L-NAME, L-arginine and BQ-123 during 30 min renal ischemia and 2 h reperfusion injury. Hepatic superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px) activities, and thiobarbituric acid-reactive substances (TBARS) and nitric oxide (NO) levels were evaluated to show hepatic response to renal I/R injury. Catalase and SOD activities showed significant differences between the control and the other groups after I/R. On the other hand, GSH-Px activity did not show any significant changes between the control and the other experimental groups mentioned under above conditions. Meanwhile, levels of TBARS were not different between the control and the other experimental groups, whereas NO level showed changes between the control and experimental groups except the one to which endothelin receptor antagonist agent (BQ-123) subjected. Experimental period may not be enough to determine the changes in GSH-Px activity and level of TBARS. However, catalase and SOD activities decreased in experimental groups treated by chemical agents. NO level decreased in chemicalagent-applied experimental groups but not in the group to which endothelin receptor antagonist BQ-123 was applied alone.en_US
dc.identifier.endpage260en_US
dc.identifier.issn0231-5882
dc.identifier.issue2en_US
dc.identifier.pmid16917132en_US
dc.identifier.scopus2-s2.0-33748352720en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage195en_US
dc.identifier.urihttps://hdl.handle.net/11616/90543
dc.identifier.volume25en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofGeneral Physiology and Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant enzymesen_US
dc.subjectLiveren_US
dc.subjectOxidationen_US
dc.subjectRenal ischemia-reperfusionen_US
dc.titleEffect of BQ-123 and nitric oxide inhibition on liver in rats after renal ischemia-reperefusion injuryen_US
dc.typeArticleen_US

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