Comparison of plasma malondialdehyde, glutathione, glutathione peroxidase, hydroxyproline and selenium levels in patients with vitiligo and healthy controls

Basit Öğe Kaydı
dc.authorscopusid7005055917
dc.authorscopusid6603280726
dc.authorscopusid6603545287
dc.authorscopusid6603317030
dc.authorscopusid7003967789
dc.contributor.authorOzturk I.
dc.contributor.authorBatcioglu K.
dc.contributor.authorKaratas F.
dc.contributor.authorHazneci E.
dc.contributor.authorGenc M.
dc.date.accessioned2024-08-04T19:59:07Z
dc.date.available2024-08-04T19:59:07Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The etiology and pathophysiologic mechanism of vitiligo are still unclear. The relationship between increased oxidative stress due to the accumulation of radicals and reactive oxygen species and the associated changes in blood and epidermal component of vitiliginous skin have been reported many times. We investigated the possible changes of plasma malondialdehyde, glutathione, selenium, hydroxyproline and glutathione peroxidase activity levels in patients with vitiligo in order to evaluate the relationship between oxidative stress and etiopathogenesis of vitiligo. Materials and Methods: Plasma malondialdehyde, glutathione, hydroxyproline and glutathione peroxidase activity levels were measured by spectrophotometric methods, and HPLC was used for measurement of selenium concentrations. Results: Our results showed increased malondialdehyde, hydroxyproline and glutathione peroxidase activity levels in plasma of vitiligo group ( P < 0.05). Conclusion: Support of antioxidant system via nonenzymatic antioxidant compounds and antioxidant enzymes may be useful to prevent of melanocyte degeneration which occur due to oxidative damage in vitiligo.en_US
dc.identifier.doi10.4103/0019-5154.39577
dc.identifier.endpage110en_US
dc.identifier.issn0019-5154
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-53849115364en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage106en_US
dc.identifier.urihttps://doi.org/10.4103/0019-5154.39577
dc.identifier.urihttps://hdl.handle.net/11616/90408
dc.identifier.volume53en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMedknow Publications and Media Pvt. Ltden_US
dc.relation.ispartofIndian Journal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFree radicalsen_US
dc.subjectOxidative damageen_US
dc.subjectSeleniumen_US
dc.subjectVitiligoen_US
dc.titleComparison of plasma malondialdehyde, glutathione, glutathione peroxidase, hydroxyproline and selenium levels in patients with vitiligo and healthy controlsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu