Improving effects of melatonin against on the histologic alterations of rat liver in diabetes

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dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidOzturk, Feral/A-2678-2016
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorVardi, Nigar
dc.contributor.authorIraz, Mustafa
dc.contributor.authorOeztuerk, Feral
dc.contributor.authorGuel, Mehmet
dc.contributor.authorUcar, Muharrern
dc.contributor.authorCetin, Asli
dc.contributor.authorNalcaci, Niluefer
dc.date.accessioned2024-08-04T20:30:38Z
dc.date.available2024-08-04T20:30:38Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This study was designed to investigate the improving effects of melatonin on the histological alterations in liver in streptozotocin (STZ)-induced diabetic rat model. Material and Methods: Fifteen Sprague-Dawley adult female rats were divided into three groups: control, diabetic and diabetic treatment with melatonin (DM) groups. Experimental diabetes was induced by a single intraperitoneal dose of STZ (45 mg/kg). After this, the DM group started to receive intraperitoneal melatonin 10 mg/kg/d. This injection was continued until the end of the study (8 week). At the end of the experimentation, blood glucose levels were determined and following routine tissue process liver were embedded in paraffin. The specimens were stained histochemically and immunohistochemically and were examined by light microscope. Results: After 8 weeks, the rats in the diabetes group had significantly higher blood glucose levels than the rats of the control and DM groups. In histological investigations, hyropic and nuclear changes were observed in hepatocytes in the diabetic group. In addition, both glycogen granules in the hepatocyte cytoplasm and mast cell granules had decreased compared with the control and DM groups. Melatonin had a positive improving effect on these findings. Conclusion: We concluded that chronic melatonin administration reduced liver injury in STZ-induced diabetic rats. Thus, we suggest that melatonin may be used to prevent the development of diabetic liver damage. However, further research is needed on long-term uses of melatonin in order to show its positive effects on diabetic complications.en_US
dc.identifier.endpage648en_US
dc.identifier.issn1300-0292
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-37049005632en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage641en_US
dc.identifier.urihttps://hdl.handle.net/11616/94411
dc.identifier.volume27en_US
dc.identifier.wosWOS:000254582800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiabetes mellitusen_US
dc.subjectliveren_US
dc.subjectmelatoninen_US
dc.subjectmast cellsen_US
dc.titleImproving effects of melatonin against on the histologic alterations of rat liver in diabetesen_US
dc.typeArticleen_US

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