Grape seed protects cholestatic rats liver from ischemia/reperfusion injury

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dc.authoridKınacı, Erdem/0000-0002-0380-7585
dc.authoridCakir, Tugrul/0000-0001-7952-8462
dc.authoridTekeli, Seckin Ozgur/0000-0002-4430-1134
dc.authorwosidÇakır, Tuğrul/AAD-1906-2019
dc.authorwosidAslaner, Arif/AAH-9024-2020
dc.authorwosidKınacı, Erdem/HTR-1780-2023
dc.authorwosidAkyüz, Cebrail/AGY-4201-2022
dc.contributor.authorCakir, Tugrul
dc.contributor.authorAslaner, Arif
dc.contributor.authorTekeli, Seckin Ozgur
dc.contributor.authorGunes, Kasim
dc.contributor.authorKinaci, Erdem
dc.contributor.authorDogan, Ugur
dc.contributor.authorTekeli, Feyza
dc.date.accessioned2024-08-04T20:41:38Z
dc.date.available2024-08-04T20:41:38Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE: To determine the effect of grape-seed extract against ischemia/reperfusion injury in cholestatic liver. METHODS: Eighteen Wistar albino rats were divided into three groups. In control and study groups, cholestasis was provided by bile duct ligation. Seven days later, the rats were subjected to 30 min hepatic ischemia, followed by 60 min of reperfusion. Oral administration of 50 mg/kg/day grape-seed extract was started 15 days before bile duct ligation and continued to the second operation in the study group. Serum, plasma and liver samples were taken. Laboratory analysis, tissue gluthation, malondialdehyde, myeloperoxidase levels and histopathological examination were performed. RESULTS: Significant decrease in liver gluthation level and significant increase in malondialdehyde level and myeloperoxidase activity were observed after ischemia/reperfusion in cholestatic rats. Serum and plasma levels for laboratory analysis were also significantly higher in cholestatic I/R group. Hepatic necrosis and fibrosis were detected in histopathological examination. Oral grape-seed extract administiration reversed all these parameters and histopathological findings except serum bilirubin levels. CONCLUSION: Oral grape-seed extract treatment can improve liver functions and attenuate the inflammation and oxidative stress in cholestatic ischemia/reperfusion injury.en_US
dc.description.sponsorshipEducational and Research Planning Funding of Antalya Training and Research Hospitalen_US
dc.description.sponsorshipEducational and Research Planning Funding of Antalya Training and Research Hospital.en_US
dc.identifier.doi10.1590/S0102-865020160030000006
dc.identifier.endpage189en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue3en_US
dc.identifier.pmid27050789en_US
dc.identifier.scopus2-s2.0-84962415020en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-865020160030000006
dc.identifier.urihttps://hdl.handle.net/11616/97252
dc.identifier.volume31en_US
dc.identifier.wosWOS:000374189100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGrape Seed Extracten_US
dc.subjectIschemiaen_US
dc.subjectInjuryen_US
dc.subjectLiveren_US
dc.subjectReperfusionen_US
dc.subjectRatsen_US
dc.titleGrape seed protects cholestatic rats liver from ischemia/reperfusion injuryen_US
dc.typeArticleen_US

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