Is Folic Acid Supplementation Really Necessary in Preterm Infants ?32 Weeks of Gestation?

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dc.authoridCalisici, Erhan/0000-0003-3461-867X
dc.authoridOncel, Mehmet Yekta/0000-0003-0760-0773
dc.authoridERDEVE, OMER/0000-0002-3193-0812
dc.authorwosidCalisici, Erhan/G-3758-2013
dc.authorwosidERDEVE, Omer/W-1480-2017
dc.authorwosidKarahan, Sevilay/E-8815-2013
dc.authorwosidOncel, Mehmet Yekta/L-5664-2013
dc.contributor.authorOncel, Mehmet Yekta
dc.contributor.authorCalisici, Erhan
dc.contributor.authorOzdemir, Ramazan
dc.contributor.authorYurttutan, Sadik
dc.contributor.authorErdeve, Omer
dc.contributor.authorKarahan, Sevilay
dc.contributor.authorDilmen, Ugur
dc.date.accessioned2024-08-04T20:38:02Z
dc.date.available2024-08-04T20:38:02Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to define whether there was folate deficiency in hospitalized preterm infants, and, second, to define the effect of feeding modalities on serum folate levels. Methods: Infants born <= 32 weeks of gestation were included in the study. Blood samples for the determination of serum folate levels were obtained on days 14 and 28 postnatally, as well as 36 weeks postconceptionally (or just before discharge if patients are discharged <36 weeks)-samples A, B, and C, respectively. Infants were divided into 3 groups based on mode of feeding; human breast milk (HBM), fortified HBM (fHBM), or preterm formula (PF). Results: A total of 162 preterm infants were enrolled: 17 (10.5%) of whom received HBM alone, 94 (58%) received fHBM, and 51 (31.5%) were fed with PF. None of the preterm infants developed folate deficiency during the study period. Preterm infants in the fHBM and PF groups had significant higher serum folate levels in samples C when compared with those receiving HBM alone (P < 0.001 for both). Multivariate analysis to evaluate the effects of maternal supplementation, smoking habit, gestational age, birth weight, and cumulative folic acid intake in samples A, B, and C suggested that maternal smoking and maternal folic acid supplementation had significant effects on serum folate levels in sample A and B. Conclusions: Preterm infants receiving parenteral nutrition with high folic acid content have no risk of folate deficiency during the 2 months of age; however, preterm infants fed orally from birth with HBM or PF with a low folic acid content could be at risk for folate deficiency, especially when mothers are smokers and/or do not receive folic acid supplementation during pregnancy.en_US
dc.identifier.doi10.1097/MPG.0000000000000181
dc.identifier.endpage192en_US
dc.identifier.issn0277-2116
dc.identifier.issn1536-4801
dc.identifier.issue2en_US
dc.identifier.pmid24051483en_US
dc.identifier.scopus2-s2.0-84894063912en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage188en_US
dc.identifier.urihttps://doi.org/10.1097/MPG.0000000000000181
dc.identifier.urihttps://hdl.handle.net/11616/96348
dc.identifier.volume58en_US
dc.identifier.wosWOS:000335379300020en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectsupplementationen_US
dc.subjectpreterm infanten_US
dc.subjectbreast milk fortifiersen_US
dc.subjectpreterm formulaen_US
dc.subjectfolic aciden_US
dc.titleIs Folic Acid Supplementation Really Necessary in Preterm Infants ?32 Weeks of Gestation?en_US
dc.typeArticleen_US

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