Oral hygiene in children with epilepsy: Effect of interleukin-1? and VEGF levels in gingival crevicular fluid

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dc.authoridDuruk, Gulsum/0000-0002-6756-6637
dc.authorwosidDuruk, Gulsum/AAM-9435-2020
dc.contributor.authorDuruk, Gulsum
dc.contributor.authorAksoy, Hulya
dc.contributor.authorGurbuz, Taskin
dc.contributor.authorLaloglu, Esra
dc.contributor.authorTan, Huseyin
dc.date.accessioned2024-08-04T20:43:04Z
dc.date.available2024-08-04T20:43:04Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. The biochemical parameters in gingival crevicular fluid (GCF) are affected by some systemic diseases and poor oral hygiene. Objectives. The aim of this study was to evaluate the total amounts of Interleukin-1 beta (IL-1 beta) and vascular endothelial growth factor ( VEGF) in GCF in children with epilepsy. Material and methods. Eighty children with epilepsy in a seizure-free period ( the test group) and 80 healthy children ( the control group) were evaluated. The children with epilepsy were taking valproic acid (VPA), carbamazepine, phenobarbital, and the combinations of these drugs. Gingival index (GI), plaque index (PI), probing depth (PD) and clinical attachment level (CAL) were measured. GCF was collected and its volume was measured. The total amounts of IL-1 beta and VEGF in the GCF were analyzed in the Biochemistry Laboratory at Ataturk University. Results. The biochemical (IL-1 beta and VEGF) and clinical parameters (GI, PI, PD and GCF volume) were significantly higher in children with epilepsy compared to healthy children (p < 0.0001). When the epilepsy patients were divided into groups according to the drug used in this study, there were no significant differences in the GCF levels of IL-1 beta and VEGF among the drug groups. Also, a significant gingival enlargement in the patient population was not recorded. Conclusions. According to these results, it may be suggested that patients need optimal oral care in epilepsy.en_US
dc.description.sponsorshipScientific Research Foundation of Ataturk University [2010/140]en_US
dc.description.sponsorshipThe study was funded by the Scientific Research Foundation of Ataturk University (grant 2010/140).en_US
dc.identifier.doi10.17219/dmp/65450
dc.identifier.endpage71en_US
dc.identifier.issn1644-387X
dc.identifier.issn2300-9020
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85016439417en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://doi.org/10.17219/dmp/65450
dc.identifier.urihttps://hdl.handle.net/11616/97766
dc.identifier.volume54en_US
dc.identifier.wosWOS:000399679100009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPolish Dental Socen_US
dc.relation.ispartofDental and Medical Problemsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectchildrenen_US
dc.subjectepilepsyen_US
dc.subjectcytokineen_US
dc.subjectgingival crevicular fluiden_US
dc.subjectoral healthen_US
dc.titleOral hygiene in children with epilepsy: Effect of interleukin-1? and VEGF levels in gingival crevicular fluiden_US
dc.typeArticleen_US

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