The activities of tissue xanthine oxidase and adenosine deaminase and the levels of hydroxyproline and nitric oxide in rat hearts subjected to doxorubicin: protective effect of erdosteine

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dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidErdogan, Hasan/AFN-9249-2022
dc.contributor.authorFadillioglu, E
dc.contributor.authorYilmaz, HR
dc.contributor.authorErdogan, H
dc.contributor.authorSogut, S
dc.date.accessioned2024-08-04T20:13:28Z
dc.date.available2024-08-04T20:13:28Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this experimental study was to investigate the effects of erdosteine, an antioxidant agent, on doxorubicin (DXR)-induced cardio-toxicity through nitric oxide (NO) levels, collagen synthesis, xanthine oxidase (XO) and adenosine deaminase (ADA) activities in rats. Rats were treated with erdosteine (10 mg/kg b.wt. per day, orally) or saline starting 2 days before administrating a single dose of DXR (20 mg/kg i.p.) or saline. At the 10th day of the DXR administration, hearts were removed under anesthesia for biochemical measurements. Enzyme activities as well as OH-proline and NO levels were found to be significantly increased in DXR group compared with the control group. All of the parameters studied except ADA activity were decreased significantly approximating to the control levels upon erdosteine administration. In conclusion, erdosteine seems to be an alternative agent for protection of cardiac tissue against DXR-induced cardio-toxicity through its regulatory effect on XO activity and NO level. (C) 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S0300-483X(03)00258-0
dc.identifier.endpage158en_US
dc.identifier.issn0300-483X
dc.identifier.issue2-3en_US
dc.identifier.pmid12965118en_US
dc.identifier.scopus2-s2.0-0142057015en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.1016/S0300-483X(03)00258-0
dc.identifier.urihttps://hdl.handle.net/11616/93640
dc.identifier.volume191en_US
dc.identifier.wosWOS:000185586000008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofToxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdoxorubicinen_US
dc.subjecterdosteineen_US
dc.subjectxanthine oxidaseen_US
dc.subjectadenosine deaminaseen_US
dc.subjectnitric oxideen_US
dc.subjecthydroxyprolineen_US
dc.titleThe activities of tissue xanthine oxidase and adenosine deaminase and the levels of hydroxyproline and nitric oxide in rat hearts subjected to doxorubicin: protective effect of erdosteineen_US
dc.typeArticleen_US

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