The Role of Insular Cortex in Response to Group Therapy in Vaginismus Patients: Magnetic Resonance Spectroscopy Study

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dc.authoridZayman, Esra Porgalı/0000-0003-1551-6782
dc.authoridERBAY, MEHMET FATİH/0000-0002-1596-3147
dc.authorwosidZayman, Esra Porgalı/ABI-2950-2020
dc.authorwosidERBAY, MEHMET FATİH/ABI-2942-2020
dc.contributor.authorErbay, Mehmet Fatih
dc.contributor.authorZayman, Esra Porgali
dc.date.accessioned2024-08-04T20:48:45Z
dc.date.available2024-08-04T20:48:45Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective Disgust has been propounded as a potential etiological factor in certain sexual dysfunctions such as vaginismus. Studies re-ports that insular cortex is activated as a response to disgust. The present study aimed to investigate the predictive role of metabolites in insular cortex in response to group therapy among vaginismus patients. Methods Study sample consisted of 51 vaginismus patients attended an ambulatory group therapy, of whom 26 benefited from 8-week group therapy and 25 were unresponsive to group therapy. All of the patients underwent H magnetic resonance spectroscopy (H-MRS), and insular cortex N-acetyl aspartate (NAA), Creatinine (Cr), Glutamine (Gln), Glutathione (GSH), Choline (Cho), Myo-inositol (mIns), Glutamate (Glu) and Lactate (Lac) concentrations were compared between the groups. Results Comparing insular cortex metabolite concentrations between the groups, Cho was statistically significantly higher (p=0.005) but mIns was significantly lower (p=0.001) in the unresponsive to group therapy group. Conclusion MR spectroscopy findings of the present study indicated significant metabolic changes such as increased Cho/Cr ratio and decreased mIns/Cr ratio in the insular cortex of vaginismus patients who were unresponsive to group therapy. Our results support the stud-ies suggesting that disgust is an important emotion in vaginismus patients and also that insula plays a role in the neurobiology of disgust.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [1855, TSA-2019-1855]en_US
dc.description.sponsorshipThis project was supported by the Inonu University Scientific Research Projects Unit (project ID: 1855; project code: TSA-2019-1855).en_US
dc.identifier.doi10.30773/pi.2019.0331
dc.identifier.endpage612en_US
dc.identifier.issn1738-3684
dc.identifier.issn1976-3026
dc.identifier.issue6en_US
dc.identifier.pmid32517415en_US
dc.identifier.scopus2-s2.0-85088607458en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage608en_US
dc.identifier.urihttps://doi.org/10.30773/pi.2019.0331
dc.identifier.urihttps://hdl.handle.net/11616/99428
dc.identifier.volume17en_US
dc.identifier.wosWOS:000545972800013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Neuropsychiatric Assocen_US
dc.relation.ispartofPsychiatry Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVaginismusen_US
dc.subjectInsular cortexen_US
dc.subjectResponsive to group therapyen_US
dc.subjectMagnetic resonance spectroscopyen_US
dc.titleThe Role of Insular Cortex in Response to Group Therapy in Vaginismus Patients: Magnetic Resonance Spectroscopy Studyen_US
dc.typeArticleen_US

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