Evaluation of reproductive and renal toxicity of varenicline in male rats

Basit Öğe Kaydı
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridSelçuk, Engin Burak/0000-0001-8484-0223
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidTopçu, ibrahim/ISV-2252-2023
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidTopcu, Ibrahim/AAH-5502-2021
dc.contributor.authorOguz, Fatih
dc.contributor.authorBeytur, Ali
dc.contributor.authorTaslidere, Elif
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorOguz, Hilal Kurnaz
dc.contributor.authorPolat, Alaaddin
dc.contributor.authorTopcu, Ibrahim
dc.date.accessioned2024-08-04T20:47:09Z
dc.date.available2024-08-04T20:47:09Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective(s): Varenicline is a selective partial agonist for the nicotinic acetylcholine receptor a4b2 subtype, which is widely used to treat smoking addiction. However, there is still no data about its potential toxic effects on tissues. In this study, we aimed to determine the varenicline-induced toxicity on reproductive and renal tissues in rats. Materials and Methods: Rats were randomly divided into two groups: control (n=10) and varenicline (n=24). Then, rats in each group were sub-divided equally as acute and chronic groups. The control rats were orally given distilled water only. Varenicline was administrated orally as follows: 1st-3rd days 9 mu g/kg/day, 4th-7th days 9 mu g/kg twice daily, and 8th-90th days 18 mu g/kg twice daily. The rats of acute and chronic groups were sacrificed on the 45th and 90th days, respectively. Some tissue markers related to oxidative stress were measured, and sperm characteristics were observed. Results: In the acute group, varenicline led to a significant decrease in SOD activities in both kidney and testis tissues. In the chronic group, varenicline significantly increased MDA and MPO production, and reduced CAT and GPx levels in the kidneys and testes. Also, SOD and GSH levels significantly decreased in the testes. Moreover, sperm characteristics were negatively affected; histopathological deformation was observed in the testes and kidneys in all groups. Conclusion: This study showed that varenicline could detrimentally affect the kidneys and testes in both acute and chronic term usage. Further studies will provide more insights into the molecular dynamics of this damage.en_US
dc.identifier.doi10.22038/IJBMS.2019.13986
dc.identifier.endpage1399en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue12en_US
dc.identifier.pmid32133056en_US
dc.identifier.scopus2-s2.0-85079768616en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1392en_US
dc.identifier.urihttps://doi.org/10.22038/IJBMS.2019.13986
dc.identifier.urihttps://hdl.handle.net/11616/99193
dc.identifier.volume22en_US
dc.identifier.wosWOS:000491224300004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofIranian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKidneyen_US
dc.subjectRaten_US
dc.subjectTestisen_US
dc.subjectToxicityen_US
dc.subjectVareniclineen_US
dc.titleEvaluation of reproductive and renal toxicity of varenicline in male ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu