Rhodium(i) N-heterocyclic carbene complexes: synthesis and cytotoxic properties

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dc.authoridŞAHİN-BÖLÜKBAŞI, Serap/0000-0003-1057-2558
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridOzdemir, Ismail/0000-0001-6325-0216
dc.authorwosidŞAHİN-BÖLÜKBAŞI, Serap/ABJ-7836-2022
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.contributor.authorSlimani, Ichraf
dc.contributor.authorSahin-Bolukbasi, Serap
dc.contributor.authorUlu, Mustafa
dc.contributor.authorEvren, Enes
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorHamdi, Naceur
dc.date.accessioned2024-08-04T20:49:25Z
dc.date.available2024-08-04T20:49:25Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRhodium(i) complexes bearing N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry, but there are very few reports of biological properties of these types of complexes. A series of benzimidazolium salts and their [RhCl(NHC)(COD)] complexes were synthesized. The obtained complexes were synthesized and characterized by elemental analysis, FT-IR, H-1 and C-13 NMR. All compounds were screened for in vitro cytotoxic activities against a panel of human cancer cells (HT-29 colon, Ishikawa endometrial, and U-87 glioblastoma) using the MTT assay for 48 h of incubation time. Mouse fibroblast cells (L-929) were used as healthy cells. Complexes had exhibited significantly higher cytotoxic activity towards cancer cells than their ligands and complex 2b showed the most selective cytotoxic activity against HT-29 cancer cells (SI;7.05) and Ishikawa cancer cells (SI; more than 9.8). The complexes showed strong in vitro cytotoxic activity against cancer cells, with IC50 values of lower than 10 mu M (except 2a against HT-29 (12.8 mu M) and 2b against U-87 (11.1 mu M)). All complexes (2a-d) showed the highest in vitro cytotoxic activity against Ishikawa endometrial cancer cells with IC50 values of 2.93 +/- 0.06, <1, 2.60 +/- 0.05, and 2.85 +/- 0.06 mu M, respectively. Complexes were found to be highly cytotoxic against HT-29, Ishikawa, and U-87 cancer cells compared to the anticancer agents, cisplatin and 5-FU.en_US
dc.description.sponsorshipnonu University Research Fund [u-BAP: FOA-2018-1135]en_US
dc.description.sponsorshipThis work was financially supported by the nonu University Research Fund (u-BAP: FOA-2018-1135). Cytotoxic activity experiments have been carried out at Sivas Cumhuriyet University Advanced Technology Research Center (CuTAM).en_US
dc.identifier.doi10.1039/d1nj00144b
dc.identifier.endpage5183en_US
dc.identifier.issn1144-0546
dc.identifier.issn1369-9261
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85102920981en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage5176en_US
dc.identifier.urihttps://doi.org/10.1039/d1nj00144b
dc.identifier.urihttps://hdl.handle.net/11616/99842
dc.identifier.volume45en_US
dc.identifier.wosWOS:000631378900028en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofNew Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keywords]en_US
dc.titleRhodium(i) N-heterocyclic carbene complexes: synthesis and cytotoxic propertiesen_US
dc.typeArticleen_US

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