The role of the arginine-nitric oxide pathway in the pathogenesis of bipolar affective disorder

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dc.authoridKocyigit, Abdurrahim/0000-0003-2335-412X
dc.authoridYanik, Medaim/0000-0001-5936-0017
dc.authorwosidVural, Hüseyin/B-3300-2016
dc.authorwosidzoroglu, suleyman s/B-2077-2012
dc.authorwosidKocyigit, Abdurrahim/P-8685-2019
dc.authorwosidZoroglu, Salih/ABD-8029-2020
dc.contributor.authorYanik, M
dc.contributor.authorVural, H
dc.contributor.authorTutkun, H
dc.contributor.authorZoroglu, SS
dc.contributor.authorSava, HA
dc.contributor.authorHerken, H
dc.contributor.authorKoçyigit, A
dc.date.accessioned2024-08-04T20:14:54Z
dc.date.available2024-08-04T20:14:54Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThere is a reciprocal regulation of arginase and nitric oxide synthase (NOS) in L-arginine-metabolizing pathways. Nitric oxide (NO) may be involved in some psychiatric disorders like schizophrenia, depression and bipolar affective disorder (BPAD). To our knowledge, there is no study in the literature in which the role of arginase, an important part of the arginine regulatory system affecting NOS activity, was investigated in BPAD. This study aims to investigate arginase, manganese (Mn) and total nitrite levels (a metabolite of NO) and their relationship to the arginine-NO pathway in patients with BPAD. Arginase activities, Mn and total nitrite levels were measured in plasma from forty-three patients with BPAD (Type one) and thirty-one healthy control subjects. Plasma arginase activities and Mn were found to be significantly lower and total nitrite level higher in patients with BPAD compared with controls. Our results suggest that the arginine-NO pathway is involved in the pathogenesis of BPAD.en_US
dc.identifier.doi10.1007/s00406-004-0453-x
dc.identifier.endpage47en_US
dc.identifier.issn0940-1334
dc.identifier.issn1433-8491
dc.identifier.issue1en_US
dc.identifier.pmid14991378en_US
dc.identifier.scopus2-s2.0-2342473952en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.1007/s00406-004-0453-x
dc.identifier.urihttps://hdl.handle.net/11616/94047
dc.identifier.volume254en_US
dc.identifier.wosWOS:000220027500008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEuropean Archives of Psychiatry and Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectarginaseen_US
dc.subjectmanganeseen_US
dc.subjectnitric oxideen_US
dc.subjectbipolar affective disorderen_US
dc.titleThe role of the arginine-nitric oxide pathway in the pathogenesis of bipolar affective disorderen_US
dc.typeArticleen_US

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