Pathogens of Intensive Care Unit-Acquired Infections and Their Antimicrobial Resistance: A 9-Year Analysis of Data from a University Hospital

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dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridmemişoğlu, funda/0000-0003-3905-1182
dc.authoridErsoy, Yasemin/0000-0001-5730-6682
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidYAKUPOGULLARI, YUSUF/F-3966-2011
dc.authorwosidmemişoğlu, funda/AAA-4392-2021
dc.authorwosidErsoy, Yasemin/AAE-4811-2020
dc.contributor.authorYetkin, Funda
dc.contributor.authorYakupogullari, Yusuf
dc.contributor.authorKuzucu, Cigdem
dc.contributor.authorErsoy, Yasemin
dc.contributor.authorOtlu, Baris
dc.contributor.authorColak, Cemil
dc.contributor.authorParmaksiz, Nalan
dc.date.accessioned2024-08-04T20:45:33Z
dc.date.available2024-08-04T20:45:33Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Pathogens surveillance and antimicrobial resistance are essential for the prompt organization of therapeutic and preventive actions in healthcare settings. Objectives: We investigated the causative agents of intensive care unit (ICU)-acquired infections and their antimicrobial resistance in a university hospital over a nine-year period. Methods: An active, prospective surveillance was conducted in the ICUs of a tertiary care hospital between 2007 and 2015. The changing patterns in the frequency of pathogens and their antimicrobial resistance by the time were statistically evaluated with Mann-Whitney U test. Results: A total of 3044 pathogens were isolated from 4272 healthcare-associated infections attacks in 3437 patients. The most frequently detected organisms were Acinetobacter spp. (n = 1060, 34.8%), Pseudomonas aeruginosa (n = 622, 20.4%), Escherichia coli (n = 340, 11.1%), Klebsiella pneumoniae (n = 331, 10.8%), and Candida spp. (n = 285, 9.3%). Carbapenem resistance among Acinetobacter spp., P. aeruginosa, E. coli, and K. pneumoniae was found as 82%, 30.7%, 2%, and 9.3%, respectively. The prevalence of extended-spectrum betalactamase (ESBL) among E. coli and K. pneumoniae was 49.7% and 41.3%, orderly, and methicillin resistance in Staphylococcus aureus was 81.8%. Substantial reductions occurred in the rates of E. coli (16.8% to 8.9%), S. aureus (11% to 3.2%), coagulase-negative staphylococci (7.9% to 0), and Stenotrophomonas maltophilia (4.2% to 0.3%) during the study period by the applied infection control measures while the rate of Acinetobacter spp. (9.7% to 51%) significantly increased. Furthermore, the increases in the carbapenem resistance among Acinetobacter spp. (52.5% to 91.4%), Pseudomonas spp. (25.7% to 51.6%), E. coli (0 to 12.7%), and K. pneumoniae (2.6% to 9%) and the decrease in the prevalence of ESBL-producing E. coli (57% to 27.2%) were statistically significant. Conclusions: Despite the decreases in the frequencies of staphylococci and some Gram-negative bacteria, the current infection control measures have been unable to limit the spread of carbapenem-resistant Gram-negative bacteria in our facility. Additional precautions are required to control such pathogens in the intensive care units.en_US
dc.identifier.doi10.5812/jjm.67716
dc.identifier.issn2008-3645
dc.identifier.issn2008-4161
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85057255878en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.5812/jjm.67716
dc.identifier.urihttps://hdl.handle.net/11616/98548
dc.identifier.volume11en_US
dc.identifier.wosWOS:000447838300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKowsar Publen_US
dc.relation.ispartofJundishapur Journal of Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHospital-Acquired Infectionen_US
dc.subjectGram-Negative Bacteriaen_US
dc.subjectCarbapenem Resistanceen_US
dc.titlePathogens of Intensive Care Unit-Acquired Infections and Their Antimicrobial Resistance: A 9-Year Analysis of Data from a University Hospitalen_US
dc.typeArticleen_US

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