pH-sensitive chitosan-PEG-decorated hollow mesoporous silica nanoparticles could be an effective treatment for acute myeloid leukemia (AML)

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dc.authoridŞahin, Adem/0000-0002-3996-2931
dc.authoridEsendagli, Gunes/0000-0003-4865-2377
dc.authoridTonbul, Hayrettin/0000-0001-5510-8973
dc.authoridUltav, Gozde/0000-0001-5582-3766
dc.authoridTavukcuoglu, Ece/0000-0003-3344-468X
dc.authorwosidŞahin, Adem/IYT-0077-2023
dc.authorwosidEsendagli, Gunes/Q-5136-2019
dc.authorwosidUltav, Gözde/JPK-6247-2023
dc.authorwosidTonbul, Hayrettin/AAR-6961-2020
dc.contributor.authorUltav, G.
dc.contributor.authorTonbul, H.
dc.contributor.authorTavukcuoglu, E.
dc.contributor.authorOzturk, S. C.
dc.contributor.authorAkbas, S.
dc.contributor.authorSahin, A.
dc.contributor.authorEsendagli, G.
dc.date.accessioned2024-08-04T20:51:41Z
dc.date.available2024-08-04T20:51:41Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractImproved treatment of acute myeloid leukemia (AML) could be possible by longer retention of anticancer drugs in the bloodstream. In this study, it was aimed to obtain improved treatment against AML by providing prolonged blood levels of doxorubicin and ensuring endosomal escape by the proton sponge effect. With this aim, pH-sensitive and chitosan-poly ethylene glycol (Cs-PEG) coated doxorubicin-loaded hollow mesoporous silica nanoparticles (C-HMSN-DN) were prepared. Nanoparticles (NPs) were characterized by dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM), X-Ray diffraction (XRD), and nitrogen adsorption-desorption isotherms. High doxorubicin encapsulation efficacy was obtained as 90%. pH-sensitive formulations were showed higher cellular uptake and found more effective against human leukemia cell line (HL60) than non-pH sensitive formulations. In vivo studies showed that Cs-PEG coating prolonged blood circulation time tremendously in comparison to unmodified nanoparticles and free doxorubicin. The designed drug delivery system (DDS) can be more effective by endosomal escape to eliminate myeloid cells which are granular cells containing a great number of lysosomes. In conclusion, we present a drug delivery system that provides a prolonged blood circulation time due to Cs-PEG coating and effective drug delivery via pH-sensitive drug release and endosomal escape for AML treatment.en_US
dc.description.sponsorshipHacettepe University Coordinatorship of Scientific Research Projects [THD-2016-12890]en_US
dc.description.sponsorshipTEM, SEM, XRD, and BET analyses were performed in Middle East Technical University Central Laboratory. Special thanks to ILKO ARGEM for FTIR analysis. A part of this study was supported by Hacettepe University Coordinatorship of Scientific Research Projects with the project code THD-2016-12890. Special thanks to Prof. Fernandez Megia and his team for giving Chitosan-PEG as a kind gift. Also, thanks to DEVA Holding A.S. for doxorubicin which was a kind gift from them.en_US
dc.identifier.doi10.1007/s11051-022-05404-8
dc.identifier.issn1388-0764
dc.identifier.issn1572-896X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85124800699en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s11051-022-05404-8
dc.identifier.urihttps://hdl.handle.net/11616/100491
dc.identifier.volume24en_US
dc.identifier.wosWOS:000753866500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Nanoparticle Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrug deliveryen_US
dc.subjectHollow mesoporous silica nanoparticles (HMSN)en_US
dc.subjectChitosan-PEGen_US
dc.subjectDoxorubicinen_US
dc.subjectAcute myeloid leukemia (AML)en_US
dc.titlepH-sensitive chitosan-PEG-decorated hollow mesoporous silica nanoparticles could be an effective treatment for acute myeloid leukemia (AML)en_US
dc.typeArticleen_US

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