Inhaled nitric oxide as rescue therapy in severe ARDS cases due to COVID-19 pneumonia: a single center experience
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Verduci Publisher
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: Inhaled NO (iNO) has been recommended as rescue therapy in acute respiratory stress syndrome (ARDS) cas-es. In this study, we aimed to demonstrate the efficacy of iNO as a rescue therapy in patients with severe ARDS due to COVID-19.PATIENTS AND METHODS: This retrospec-tive study included patients with ARDS due to COVID-19 who were treated with iNO between March 2020 and January 2022 in the intensive care unit (ICU) of Inonu University. Patients' files were reviewed retrospectively, and de-mographic data, APACHE II and Sequential Or-gan Failure Assessment (SOFA) scores, initia-tion day of iNO and duration of iNO treatment, length of stay in hospital/ICU, blood biochem-istry values, complete blood counts, inflamma-tory parameters, arterial blood gas values, lac-tate, PaO2/FiO2 ratios, anti-inflammatory drugs and outcome were recorded.RESULTS: Data from 16 patients were reached. iNO was given at a dose of 20 ppm continuously. The mean duration of treatment with iNO was 3.5 days. All patients took the prone position except a single patient. While all patients received steroid therapy, four pa-tients received anti-cytokine therapy, and five patients received intravenous immunoglobulin therapy. All patients were in severe ARDS with a mean PaO2/FiO2 ratio of 58 before iNO ther-apy. A significant increase in PaO2/FiO2 val-ues was detected with the use of iNO (p<0.05). While three patients (19%) were discharged from the ICU, thirteen patients died.CONCLUSIONS: In our study, it was deter-mined that iNO applied as a rescue treatment in patients with severe ARDS improved oxygen-ation. Although the effect of iNO on survival was low, it may be interpreted as clinically signifi-cant considering the severity of the general clin-ical condition of the patients.
Açıklama
Anahtar Kelimeler
Acute respiratory distress syndrome, Inhaled nitric oxide, COVID-19, Intensive care, Mortality
Kaynak
European Review For Medical and Pharmacological Sciences
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
27
Sayı
13
