Integration of Mycobacterium tuberculosis Drug Susceptibility Testing and Genotyping with Epidemiological Data Analysis To Gain Insight into the Epidemiology of Drug-Resistant Tuberculosis in Malatya, Turkey

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dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridAgarwal, Mansi/0000-0002-0367-7733
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.contributor.authorAgarwal, Mansi
dc.contributor.authorGunal, Selami
dc.contributor.authorDurmaz, Riza
dc.contributor.authorYang, Zhenhua
dc.date.accessioned2024-08-04T20:32:32Z
dc.date.available2024-08-04T20:32:32Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDrug-resistant tuberculosis (TB) presents a major challenge to global TB control. To gain a better understanding of drug-resistant TB epidemiology in Malatya, Turkey, we conducted the present study using 397 Mycobacterium tuberculosis clinical isolates collected from Malatya, Turkey, in recent years (2000-2007). Resistance to any anti-TB drug was found in 29% (114 of 397) of the study isolates, while the multidrug resistance (MDR) rate was similar to 4.5% (18 of 397). Resistances to isoniazid (15.5%) and streptomycin (13.4%) were about twice as high as resistance to rifampin (RMP) (6.3%) and ethambutol (EMB) (6.0%). Importantly, 28% (7 of 25) of the RMP-resistant isolates were non-MDR isolates, as when a significant proportion of RMP-resistant isolates in a population are non-MDR, the predictive value of molecular detection of RMP resistance for MDR can be significantly reduced. Both identical and varied drug resistance patterns were seen in the same genotyping-defined clusters, suggesting that both primary and acquired resistance have contributed to the drug-resistant TB epidemic in Malatya, Turkey. In addition, drug-resistant cases were found to be more likely to be males (odds ratio [95% confidence interval], 1.82 [1.13, 2.94]), suggesting a potential role of gender in the epidemiology of drug-resistant TB in the study population. This study demonstrates that the integration of drug susceptibility testing with genotyping and epidemiological data analysis represents a useful approach to studying the epidemiology of drug-resistant TB.en_US
dc.description.sponsorshipMolecular and Clinical Microbiology Society, Malatya, Turkey; University of Michiganen_US
dc.description.sponsorshipThis study was supported by a grant from the Molecular and Clinical Microbiology Society, Malatya, Turkey, and the Elizabeth Crosby Award of the University of Michigan.en_US
dc.identifier.doi10.1128/JCM.02459-09
dc.identifier.endpage3305en_US
dc.identifier.issn0095-1137
dc.identifier.issn1098-660X
dc.identifier.issue9en_US
dc.identifier.pmid20660214en_US
dc.identifier.scopus2-s2.0-77956800473en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3301en_US
dc.identifier.urihttps://doi.org/10.1128/JCM.02459-09
dc.identifier.urihttps://hdl.handle.net/11616/95133
dc.identifier.volume48en_US
dc.identifier.wosWOS:000281480400040en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Soc Microbiologyen_US
dc.relation.ispartofJournal of Clinical Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPulmonary Tuberculosisen_US
dc.subjectMolecular Epidemiologyen_US
dc.subjectRifampicin Resistanceen_US
dc.subjectRisk-Factorsen_US
dc.subjectPopulationen_US
dc.subjectStrainsen_US
dc.subjectPrevalenceen_US
dc.subjectDiagnosisen_US
dc.subjectRegionsen_US
dc.titleIntegration of Mycobacterium tuberculosis Drug Susceptibility Testing and Genotyping with Epidemiological Data Analysis To Gain Insight into the Epidemiology of Drug-Resistant Tuberculosis in Malatya, Turkeyen_US
dc.typeArticleen_US

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