Protective effect of resveratrol against pembrolizumab-induced hepatotoxicity and neurotoxicity in male rats

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dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridASKIN OZEK, DILAN/0000-0001-9075-4807
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authoridyuce, hande/0000-0003-2907-2019
dc.authoridunuvar, songul/0000-0001-8454-490X
dc.authoridCETIN, Asli/0000-0003-3902-3210
dc.authorwosidbasak, nese/ABH-5495-2020
dc.contributor.authorTurkmen, Nese B.
dc.contributor.authorYuce, Hande
dc.contributor.authorSahin, Yasemin
dc.contributor.authorTaslidere, Asli C.
dc.contributor.authorOzek, Dilan A.
dc.contributor.authorUnuvar, Songul
dc.contributor.authorCiftci, Osman
dc.date.accessioned2024-08-04T20:53:12Z
dc.date.available2024-08-04T20:53:12Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe present study investigates the effects of resveratrol (RSV) on brain and liver tissues in rats with pembrolizumab (PEMB)-induced toxicity. Obtained for the study were 28 male Sprague-Dawley rats (3-4 months old) which were divided into four groups: Group 1: Control. Group 2: Administered PEMB at 5 mg/kg/day i.p. for a week. Group 3: Administered RSV orally at the dose of 20 mg/kg/day for 30 days by gavage. Group 4: Administered PEMB and RSV at 20 and 5 mg/kg/day RSV, respectively, for 30 days. The results of this study revealed that PEMB leads to a significant increase in thiobarbituric acid reactive substance (TBARS) levels and a significant decrease in glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) activities, and glutathione (GSH) levels in the liver and brain tissues. The decreased SOD, CAT, GPx activities, and GSH levels increased significantly following RSV treatment in Group 4. The PEMB treatment showed histopathological alterations associated with strong positive cysteinyl aspartic acid-protease-3 (caspase-3) immunoreactivity, while RSV treatment reduced both the expression of caspase-3 protein and the histopathological changes. RSV administration prevents the biochemical, immunological, and histological alterations induced by PEMB. It can be suggested that the lower caspase-3 immunoreactivity in the PEMB + RSV group than in the PEMB group led to an inhibition of RSV on apoptosis.en_US
dc.identifier.doi10.1002/jbt.23263
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue3en_US
dc.identifier.pmid36419233en_US
dc.identifier.scopus2-s2.0-85142631308en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.23263
dc.identifier.urihttps://hdl.handle.net/11616/101017
dc.identifier.volume37en_US
dc.identifier.wosWOS:000889868200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthepatotoxicityen_US
dc.subjectneurotoxicityen_US
dc.subjectoxidative stressen_US
dc.subjectpembrolizumaben_US
dc.subjectresveratrolen_US
dc.titleProtective effect of resveratrol against pembrolizumab-induced hepatotoxicity and neurotoxicity in male ratsen_US
dc.typeArticleen_US

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