Plasma endothelin-1, homocysteine and serum nitric oxide values in patients with left-to-right shunt

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dc.authorscopusid6603062857
dc.authorscopusid55400541100
dc.authorscopusid6603405386
dc.authorscopusid6701341322
dc.authorscopusid6604070029
dc.authorscopusid6602609706
dc.authorscopusid7006330235
dc.contributor.authorOzerol I.H.
dc.contributor.authorPac F.A.
dc.contributor.authorOzerol E.
dc.contributor.authorEge E.
dc.contributor.authorYologlu S.
dc.contributor.authorTemel I.
dc.contributor.authorPac M.
dc.date.accessioned2024-08-04T19:59:07Z
dc.date.available2024-08-04T19:59:07Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: This study aimed to evaluate the effect of pulmonary blood flow and pulmonary hypertension on plasma endothelin-1, homocysteine and serum nitric oxide levels in patients with left-to-right shunt lesions with pulmonary hypertension and also with normal pulmonary arterial pressure. Methods and Results: Plasma endothelin-1, homocysteine and nitric oxide levels were measured in 44 patients (Group 1) with left-to-right shunt and normal pulmonary arterial pressure (Qp/Qs: 2.1), 65 patients (Group 2) with left-to-right shunt and pulmonary hypertension (Qp/Qs: 2.4), 20 healthy control subjects (Group 3), and 17 post-operative patients (Group 4). Plasma endothelin-1 and serum nitric oxide levels were significantly higher in Group 2 than in groups 1, 3, and 4 (p<0.001). Plasma homocysteine levels were significantly higher in Group 2 than in Groups 1 and 4 (p<0.001 and p<0.01, respectively). Conclusions: The increase in serum nitric oxide levels in patients with left-to-right shunt and pulmonary hypertension may be attributed to the compensatory mechanism. However, this increase does not improve pulmonary hypertension because of increased endothelin-1 and homocysteine levels. In the light of present study, we conclude that vascular changes caused by increased homocysteine and endothelin-1 may provoke pulmonary hypertension in patients with left-to-right shunt.en_US
dc.identifier.endpage657en_US
dc.identifier.issn0019-4832
dc.identifier.issue6en_US
dc.identifier.pmid15751522en_US
dc.identifier.scopus2-s2.0-14144249456en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage653en_US
dc.identifier.urihttps://hdl.handle.net/11616/90404
dc.identifier.volume56en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofIndian Heart Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCongenital heart diseaseen_US
dc.subjectLeft-to-right shunten_US
dc.subjectNitric oxideen_US
dc.titlePlasma endothelin-1, homocysteine and serum nitric oxide values in patients with left-to-right shunten_US
dc.typeArticleen_US

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