Aktif akciğer tüberkülozlu hastalarda antitüberküloz tedavinin serum akut faz reaktanlarının konsantrasyonu üzerine etkisi
Küçük Resim Yok
Tarih
1999
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Türkiye Tıp Dergisi Dahili Tıp Bilimleri
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Öz: Tilberkillozlu hastalarda akuffaz reaktanlarinin, tedaviye cevabi ve hasiahgin aktivitesini belirlemede muhte- mel marker olabilecegi one silrulmektedir. Aktif akciger tiiberkulozu olan 30 hastada akutfaz reaktanlan uze¬ rine tuberkiiloz tedavisinin etkisini degerlendirmek if in, tedaviden Once ve tedavinin 6. aymda serum trans- ferrin, albumin ve kompleman C3 ve C4 gibi akutfaz reaktanlarinin seviyelerini ve eritrosit sedimantasyon, hi- zini (ESH) b'lgtuk. Turn akutfaz reaktanlarinin serum seviyeleri normal sinirlar icinde olasina ragmen, teda- vi sirasmda duzeylerinde degisiklikler meydana geldi. Transferrin (190,6 ± 55,9 dan 222,8 ± 76,3 mg/dL'ye) (p<0.007) ve albumin (4,0 ± 0,7dan 4,7± 0,4g/dL'ye) (p<0.0001), seviyeleri tuberkiiloz tedavisiyle artarken, kompleman C3 (173,7 ±5,8 dan 121,2 ± 31,5 mg/dL'ye) diizeyinde azalma goriildu (p<0.0001). Kompleman C4 diizeyinde onemli degisiklik gdriilmedi. ESH baslangigta yilksek (50 ± 20 mm/saat) olarak olguldiX ve teda- viyle normale (10 ± 3 mm/saat) dondii (p<0.0001). Sonugta ESHyamnda transferrin, albumin ve kompleman C3 dilzeylerinin tuberkulozda tedavi cevabinin izlenmesinde kullanish bir marker olarak degerlendirilebilece- gi dusilnilldu.
Abstract: Several acute phase reactant levels have been proposed as possible markers to monitor disease activity and res¬ponse to the treatment in patients with tuberculosis. In order to evaluate the effect of anti-tuberculous che¬motherapy on acute phase reactants, we measured the serum levels such of acute phase reactants as transfer¬rin, albumin, complement C3 and C4 and erytrocyte sedimentation rate (ESR) in 30 patients with active pul¬monary tuberculosis before and after anti-tuberculous chemotherapy. Although all acute phase reactant levels were within normal limits, before and after the treatment their levels changed during treatment. While there we¬re an increase in the concentrations of transferrin (190,6± 55,9 versus 222,8 ± 76,3 mg/dl) (p<0.007) and al¬bumin (4,0 ± 0,7 versus 4,7 ± 0,4 g/dL) (p<0.0001), there was a significant decrease in complement C3 level (173,7 ± 5,8 versus. 121,2 ± 31,5 mg/dL) (p<0.0001) in patients with pulmonary tuberculosis. The ESR before treatment significantly increased (50 ± 20 mm/h) and returned to the normal levels (10 ± 3 mm/h) after 6 months of anti-tuberculous treatment (p< 0.0001). No significant decrease was observed in the level ofcomplement C4. In conclusion, transferrin, complement C3 and albumin are considered to be the biochemical mar-&#9632; kers capable of being used to predict and monitor the clinical response to the chemotherapy
Abstract: Several acute phase reactant levels have been proposed as possible markers to monitor disease activity and res¬ponse to the treatment in patients with tuberculosis. In order to evaluate the effect of anti-tuberculous che¬motherapy on acute phase reactants, we measured the serum levels such of acute phase reactants as transfer¬rin, albumin, complement C3 and C4 and erytrocyte sedimentation rate (ESR) in 30 patients with active pul¬monary tuberculosis before and after anti-tuberculous chemotherapy. Although all acute phase reactant levels were within normal limits, before and after the treatment their levels changed during treatment. While there we¬re an increase in the concentrations of transferrin (190,6± 55,9 versus 222,8 ± 76,3 mg/dl) (p<0.007) and al¬bumin (4,0 ± 0,7 versus 4,7 ± 0,4 g/dL) (p<0.0001), there was a significant decrease in complement C3 level (173,7 ± 5,8 versus. 121,2 ± 31,5 mg/dL) (p<0.0001) in patients with pulmonary tuberculosis. The ESR before treatment significantly increased (50 ± 20 mm/h) and returned to the normal levels (10 ± 3 mm/h) after 6 months of anti-tuberculous treatment (p< 0.0001). No significant decrease was observed in the level ofcomplement C4. In conclusion, transferrin, complement C3 and albumin are considered to be the biochemical mar-&#9632; kers capable of being used to predict and monitor the clinical response to the chemotherapy
Açıklama
Yıl: 1999Cilt: 6Sayı: 3ISSN: 1300-9338Sayfa Aralığı: 139 - 142Metin Dili:Türkçe
Anahtar Kelimeler
Kaynak
Türkiye Tıp Dergisi Dahili Tıp Bilimleri
WoS Q Değeri
Scopus Q Değeri
Cilt
6
Sayı
3
Künye
YILDIRIM Z,ŞAHİN A,BÜYÜKBERBER N,GÖKIRMAK M,HACIEVLİYAGİL S (1999). Aktif akciğer tüberkülozlu hastalarda antitüberküloz tedavinin serum akut faz reaktanlarının konsantrasyonu üzerine etkisi. Türkiye Tıp Dergisi Dahili Tıp Bilimleri, 6(3), 139 - 142.
