Post-Process Cytotoxicity of Resins in Clear Aligner Fabrication

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dc.contributor.authorBor, Sabahattin
dc.contributor.authorKaya, Yesim
dc.contributor.authorDemiral, Ayse
dc.contributor.authorGungormus, Mustafa
dc.date.accessioned2026-04-04T13:30:58Z
dc.date.available2026-04-04T13:30:58Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractThis study aimed to evaluate the cytotoxicity of two resin materials, Tera Harz TC-85 DAC and Clear-A, along with the effects of two different post-printing protocols applied to Clear-A. Samples were produced using the Ackuretta Sol printer. The following three groups were formed based on the resins used and the post-curing methods applied: Group 1: Tera Harz TC-85 DAC resin + Tera Harz Cure; Group 2: Clear-A resin + Curie machine; and Group 3: Clear-A resin + Tera Harz Cure. All samples were sterilized in 70% ethanol for 5 min, rinsed with sterile deionized water, and incubated in Dulbecco's Modified Eagle Medium at 37 degrees C for 72 h. Cytotoxicity assessment was performed by the XTT and RTCA methods using the human gingival fibroblast cell line. According to the XTT assay, undiluted resin extracts exhibited approximately 75-80% cell viability at 24 h, while further dilutions resulted in a viability exceeding 90%. No significant differences in viability were observed among the groups at any dilution at 48 and 72 h. The xCELLigence RTCA results aligned with the XTT findings, showing a transient decrease in cell viability within the first 24 h, followed by continued cell growth. This study demonstrated that extracts from all tested 3D-printed resins exhibited biocompatibility with human gingival fibroblasts. These findings support their potential for further applications in the dental and biomedical fields.
dc.identifier.doi10.3390/polym17131776
dc.identifier.issn2073-4360
dc.identifier.issue13
dc.identifier.orcid0000-0001-5463-0057
dc.identifier.orcid0000-0002-5795-7327
dc.identifier.orcid0000-0001-8894-0467
dc.identifier.orcid0000-0001-8547-6558
dc.identifier.pmid40647786
dc.identifier.scopus2-s2.0-105010301716
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/polym17131776
dc.identifier.urihttps://hdl.handle.net/11616/108487
dc.identifier.volume17
dc.identifier.wosWOS:001526158100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofPolymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subject3D-printed clear aligners
dc.subjectTera Harz TC-85 DAC resin
dc.subjectClear-A resin
dc.subjectCytotoxicity
dc.titlePost-Process Cytotoxicity of Resins in Clear Aligner Fabrication
dc.typeArticle

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